Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

    May 2019 in “Cells
    Pietro Gentile, Simone Garcovich
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    TLDR Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
    The 2019 review by Pietro Gentile and Simone Garcovich discussed the potential of stem cell therapy in treating hair loss and androgenic alopecia. The authors focused on adipose-derived stromal vascular cells, platelet-rich plasma, and human follicle mesenchymal stem cells due to their ability to differentiate into various cell lineages and enhance cell multiplication and neo-angiogenesis. The review emphasized the role of Wnt signaling in dermal papilla cells, which is key in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets were found to influence hair growth through cellular proliferation, inducing cell growth, stimulating hair follicle development, and suppressing apoptotic cues. However, the review called for larger, randomized, double-blinded, controlled trials to optimize cell administration protocols and confirm early observations of promising clinical outcomes.
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