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    Minoxidil Use in Dermatology, Side Effects, and Recent Patents

    April 2012 in “ Recent Patents on Inflammation & Allergy Drug Discovery ”
    Alfredo De Rossi, Carmen Cantisani, Luca Melis … Stefano Calvieri
    Studysummary This review describes minoxidil's hair regrowth mechanism and discusses dermatological applications, but reports no new clinical results, emphasizing the need for regular use and addressing allergic reactions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 61

    1. Marie-Unna Hereditary Hypotrichosis: Case Report and Review of the Literature Pediatric dermatology · 2011
    2. Alopecia Areata Incognita: A Case Report Clinics · 2011
    3. Monilethrix Treated with Minoxidil International Journal of Immunopathology and Pharmacology · 2011
    4. Chemotherapy-Induced Hair Loss PubMed · 2010
    5. Identification of Transcriptional Targets of Wnt/β-Catenin Signaling in Dermal Papilla Cells of Human Scalp Hair Follicles: EP2 Is a Novel Transcriptional Target of Wnt3a Journal of Dermatological Science · 2010
    6. A New Approach to Treating Scarring Alopecia by Hair Transplantation and Topical Minoxidil Indian Journal of Dermatology, Venereology and Leprology · 2010
    7. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009
    8. Contemporary Hair Transplantation Dermatologic Surgery · 2009
    9. Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes Skin Pharmacology and Physiology · 2009
    10. Alopecia Areata: Evidence-Based Treatments Seminars in cutaneous medicine and surgery · 2009
    11. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    12. Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis Matrix Biology · 2005
    13. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    14. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    15. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    16. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    17. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    18. A Case of Acute Myocardial Infarction Associated with Topical Use of Minoxidil for Treatment of Baldness Japanese Heart Journal · 2000
    19. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    20. The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall British Journal of Dermatology · 1999
    21. Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp Journal of Dermatological Science · 1999
    22. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    23. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    24. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    25. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    26. In the Absence of Streptomycin, Minoxidil Potentiates the Mitogenic Effects of Fetal Calf Serum, Insulin-Like Growth Factor 1, and Platelet-Derived Growth Factor on NIH 3T3 Fibroblasts in a K+ Channel-Dependent Fashion Journal of Investigative Dermatology · 1996
    27. Inhibitory Effects of bFGF, VEGF, and Minoxidil on Collagen Synthesis by Cultured Hair Dermal Papilla Cells Archives of Dermatological Research · 1996
    28. Improvement in Androgenetic Alopecia (Stage V) Using Topical Minoxidil in a Retinoid Vehicle and Oral Finasteride Archives of Dermatology · 1995
    29. Relative Influence of Ethanol and Propylene Glycol Cosolvents on Deposition of Minoxidil into the Skin Journal of Pharmaceutical Sciences · 1994
    30. Minoxidil Sulfation in the Hair Follicle Skin Pharmacology and Physiology · 1994
    31. Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts Archives of Biochemistry and Biophysics · 1994
    32. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    33. Organ Culture of Human Hair Follicles in Serum-Free Medium Archives of Dermatological Research · 1993
    34. Minoxidil: Update on Its Clinical Role PubMed · 1993
    35. Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures Skin Pharmacology and Physiology · 1993
    36. Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil Biochemical Pharmacology · 1993
    37. Minoxidil Sulfotransferase, A Marker Of Human Keratinocyte Differentiation Journal of Investigative Dermatology · 1992
    38. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    39. Interaction of Minoxidil with Pigment in Cells of the Hair Follicle: An Example of Binding Without Apparent Biological Effects Skin Pharmacology and Physiology · 1992
    40. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991
    41. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    42. Sulfation of Minoxidil by Human Liver Phenol Sulfotransferase Biochemical Pharmacology · 1990
    43. Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution Journal of Pharmaceutical Sciences · 1990
    44. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    45. Sulfation of Minoxidil in Keratinocytes and Hair Follicles PubMed · 1989
    46. Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia Clinics in Dermatology · 1988
    47. Mechanism of Action of Minoxidil Sulfate-Induced Vasodilation: A Role for Increased Potassium Permeability PubMed · 1988
    48. Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture Biochemical Pharmacology · 1988
    49. Does Topical Minoxidil Increase Skin Blood Flow? A Laser Doppler Flowmetry Study PubMed · 1988
    50. Sulfation of Minoxidil by Human Platelet Sulfotransferase Clinica Chimica Acta · 1987
    51. Alterations in Scalp Blood Flow After the Epicutaneous Application of 3% Minoxidil and 0.1% Hexyl Nicotinate in Alopecia British Journal of Dermatology · 1987
    52. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987
    53. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987
    54. Hypertrichosis and Congenital Anomalies Associated With Maternal Use of Minoxidil Pediatrics · 1987
    55. Topical Minoxidil in Early Male Pattern Baldness Journal of The American Academy of Dermatology · 1985
    56. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984
    57. Direct Effects of Minoxidil on Epidermal Cells in Culture Journal of Investigative Dermatology · 1984
    58. Effect of Minoxidil on Cultured Keratinocytes Journal of Investigative Dermatology · 1983
    59. Unusual Hair Changes with Minoxidil Therapy International Journal of Dermatology · 1983
    60. Sulfation of Minoxidil by Liver Sulfotransferase Biochemical Pharmacology · 1982
    61. Reversal of Baldness in Patient Receiving Minoxidil for Hypertension The New England Journal of Medicine · 1980

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    3. Hair Loss (Alopecia or Baldness) 2018
    4. Treatments of Hereditary Hair Loss (Alopecia) 2018
    5. Disorders of Hair DeckerMed Medicine · 2013
    6. Characteristics of Korean Scalp Hair and Male Pattern Baldness Journal of The Korean Medical Association · 2013
    7. Is Topical Minoxidil Solution Effective on Androgenetic Alopecia in Routine Daily Practice? Journal of Dermatological Treatment · 2007
    8. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987