Minoxidil Use in Dermatology, Side Effects and Recent Patents
May 2012
in “Recent Patents on Inflammation & Allergy Drug Discovery”
TLDR Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.
This document discusses the use of minoxidil in dermatology, including its side effects and recent patents. Minoxidil is a medication used to treat hair loss and promote hair growth. It is now used topically in a 2% concentration for female androgenic alopecia and 5% for male androgenic alopecia. The mechanism by which it promotes hair growth is not fully understood, but it is believed to widen blood vessels and open potassium channels, allowing more oxygen, blood, and nutrients to the follicle. Side effects are common, including irritant and allergic contact dermatitis on the scalp, and increased hair loss due to synchronization of the hair cycle. The article also mentions recent patents related to the use of minoxidil in combination with other medications for hair growth and the use of potassium channel openers for hair growth.
View this study on eurekaselect.com →
Cited in this study
research Monilethrix Treated with Minoxidil
Minoxidil 2% effectively treats Monilethrix without side effects.
research Alopecia areata incognita
A young woman with a rare hair loss condition improved with steroid and biotin treatment.
research Identification of transcriptional targets of Wnt/β-catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 is a novel transcriptional target of Wnt3a
Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.
research A new approach to treating scarring alopecia by hair transplantation and topical minoxidil
Hair transplant and applying 5% minoxidil solution can effectively treat permanent hair loss, but it may change hair direction in some cases.
research Contemporary Hair Transplantation
Modern hair transplants use small grafts for a natural look and drugs to prevent further loss, with high patient satisfaction.
research Medical treatments for male and female pattern hair loss
Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.
research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis
Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
research Minoxidil: mechanisms of action on hair growth
Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
research Hypertrichosis in females applying minoxidil topical solution and in normal controls
Minoxidil use increases facial hair growth in females, more in older users.
research A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men
5% minoxidil works better for hair growth and density, with minor irritation.
research Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment
Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.
research Control of hair growth and follicle size by VEGF-mediated angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
research A Case of Acute Myocardial Infarction Associated with Topical Use of Minoxidil (RiUP) for Treatment of Baldness.
A man developed heart problems after using a baldness treatment for 4 months, suggesting that people with heart issues should avoid this treatment.
research Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment
Minoxidil increases hair weight and count temporarily in men with hair loss.
research The induction by topical minoxidil of increased fenestration in the perifollicular capillary wall
Minoxidil increased small openings in blood vessel walls near growing hair in rats.
research Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp
Minoxidil boosts enzymes that help hair growth.
research Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells
Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.
research Sulfation of minoxidil by multiple human cytosolic sulfotransferases
Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.
research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes
Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.
research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect
Minoxidil boosts hair growth by activating PGHS-1.
research Diffuse hypertrichosis during treatment with 5% topical minoxidil
research Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells
bFGF, VEGF, and minoxidil decrease collagen production in hair cells, possibly affecting hair growth.
research Improvement in Androgenetic Alopecia (Stage V) Using Topical Minoxidil in a Retinoid Vehicle and Oral Finasteride
Combination therapy improves hair growth in advanced hair loss.
research Relative Influence of Ethanol and Propylene Glycol Cosolvents on Deposition of Minoxidil into the Skin
Ethanol over 50% helps minoxidil absorb better into skin.
research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts
Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.
research Minoxidil Sulfation in the Hair Follicle
Minoxidil helps hair growth by activating enzymes in hair follicles.
research Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil
Minoxidil needs activation to work, and minoxidil sulfate helps with hair growth and blood pressure.
research Minoxidil Sulfotransferase, a Marker of Human Keratinocyte Differentiation
Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
research Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles
Minoxidil works in liver and outer hair root sheath for hair growth.
research Minoxidil Sulfate Is the Active Metabolite that Stimulates Hair Follicles
Minoxidil sulfate stimulates hair growth.
research Sulfation of minoxidil by human liver phenol sulfotransferase
Minoxidil activates hair growth by being sulfated by P-PST in the human liver.
research Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution
Longer contact time increases minoxidil absorption, but doesn't affect metabolism.
research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats
Minoxidil speeds up hair growth in rats without prolonging growth phase.
research Histologic response to topically applied minoxidil in male-pattern alopecia
Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.
research Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.
Minoxidil sulfate relaxes muscle by increasing potassium flow, making it a unique muscle relaxer.
research Selective inhibition by minoxidil of prostacyclin production by cells in culture
Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.
research Sulfation of minoxidil by human platelet sulfotransferase
Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
research Alterations in scalp blood flow after the epicutaneous application of 3% minoxidil and 0.1% hexyl nicotinate in alopecia
Minoxidil didn't increase scalp blood flow for hair growth, but hexyl nicotinate did.
research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.
Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
research Action of topical minoxidil in the bald stump-tailed macaque
Minoxidil promotes hair growth but stops working when discontinued.
research Hypertrichosis and Congenital Anomalies Associated With Maternal Use of Minoxidil
Minoxidil use during pregnancy can cause excessive hair growth and multiple birth defects in the baby.
research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action
Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.
research Topical minoxidil in early male pattern baldness
Minoxidil promotes hair growth in male pattern baldness.
research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography
Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.
research Direct Effects of Minoxidil on Epidermal Cells in Culture
Minoxidil promotes hair growth by increasing cell division and DNA synthesis.
research Effect of Minoxidil on Cultured Keratinocytes
Minoxidil helps hair cells live longer and grow longer.
research Sulfation of minoxidil by liver sulfotransferase
Liver enzyme helps minoxidil work better for blood vessel relaxation.
research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension
Minoxidil helped bald patient regrow hair.
Related
research Role of low dose oral minoxidil in the treatment of hair loss: A review
research Hair loss (alopecia or baldness)
Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.
research Treatments of hereditary hair loss (alopecia)
Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.
research Disorders of Hair
The document's conclusion cannot be provided because the document is not readable or understandable.
research 한국인의 두피모발 특성과 남성형탈모증
The document's conclusion cannot be provided because the text is in Korean and cannot be parsed.
research Is topical minoxidil solution effective on androgenetic alopecia in routine daily practice?
Minoxidil solution had low effect, causing 99% to stop using it.
research Topical minoxidil in male pattern baldness: Effects of discontinuation of treatment
Stopping minoxidil treatment resumes balding; continuous use needed for results.