Marie-Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

March 2011 in “ Pediatric dermatology ”

Joshua O. Podjasek, Jennifer L. Hand

Marie‐Unna hereditary hypotrichosis autosomal dominant hereditary hair loss hair thinning hair loss

TLDR An 18-year-old girl was diagnosed with a rare hereditary hair loss condition, despite no family history.

An 18-year-old girl experienced progressively worsening hair thinning and loss since puberty, diagnosed as Marie-Unna hereditary hypotrichosis, a rare autosomal dominant hereditary hair loss condition. Despite no family history of similar hair loss, this case represented the first report of Marie-Unna hereditary hypotrichosis in a previously unaffected family. The diagnosis was confirmed through clinical history, physical examination, and pathology results.

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Research cited in this study

3 / 3 results

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

181 citations, January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research Office Diagnosis of Hair Shaft Defects

33 citations, March 2006 in “Seminars in cutaneous medicine and surgery”

The document explains how to identify different hair problems using a microscope.

research A Distinct Gene Close to the Hairless Locus on Chromosome 8p Underlies Hereditary Marie Unna Type Hypotrichosis in a German Family

36 citations, October 2000 in “British Journal of Dermatology”

A different gene near the hairless gene on chromosome 8p21 causes a rare hair loss condition in a German family.

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