Marie-Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

March 2011 in “ Pediatric dermatology ”

Joshua O. Podjasek, Jennifer L. Hand

Marie‐Unna hereditary hypotrichosis autosomal dominant hereditary hair loss hair thinning hair loss

Studysummary This report describes a new case of Marie-Unna hereditary hypotrichosis in an 18-year-old girl, marking the first occurrence in a previously unaffected family.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

An 18-year-old girl experienced progressively worsening hair thinning and loss since puberty, diagnosed as Marie-Unna hereditary hypotrichosis, a rare autosomal dominant hereditary hair loss condition. Despite no family history of similar hair loss, this case represented the first report of Marie-Unna hereditary hypotrichosis in a previously unaffected family. The diagnosis was confirmed through clinical history, physical examination, and pathology results.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

181 citations , January 2009 in “Nature Genetics”

In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.

research Office Diagnosis of Hair Shaft Defects

33 citations , March 2006 in “Seminars in cutaneous medicine and surgery”

This article illustrates various hair shaft defects and suggests that dermatologists can diagnose most of them using light microscopy and polarization without needing advanced imaging techniques.

research A Distinct Gene Close to the Hairless Locus on Chromosome 8p Underlies Hereditary Marie Unna Type Hypotrichosis in a German Family

36 citations , October 2000 in “British Journal of Dermatology”

This study identified a distinct gene near the hairless locus on chromosome 8p that is responsible for hereditary Marie Unna type hypotrichosis in a German family.