Minoxidil: Update on Its Clinical Role

January 1993 in “ PubMed ”

R Savin, Andrew V. Atton

minoxidil hair-growing agents hair loss hair restoration therapies Rogaine

TLDR Minoxidil was crucial in advancing scientific research and treatments for hair loss.

The document reviewed the clinical role of minoxidil in the early 1990s, highlighting its significance as the first scientifically-backed hair-growing agent. Prior to minoxidil, the field of hair loss treatment was largely unregulated and dominated by ineffective remedies. The introduction of minoxidil marked a shift towards serious scientific research in treating common baldness, paving the way for future advancements in hair growth treatments.

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Research cited in this study

40 / 40 results

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride and minoxidil together promote hair growth better than either alone.

research Minoxidil: Inhibition of Proliferation of Keratinocytes In Vitro

14 citations , September 1991 in “Journal of Investigative Dermatology”

Minoxidil slows down keratinocyte growth without being toxic.

research Contact Dermatitis in Reaction to 2% Topical Minoxidil Solution

23 citations , April 1991 in “Journal of The American Academy of Dermatology”

Minoxidil solution can cause skin irritation and allergies in some users.

research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

166 citations , November 1990 in “Journal of Investigative Dermatology”

Minoxidil sulfate stimulates hair growth.

research Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution

25 citations , June 1990 in “Journal of Pharmaceutical Sciences”

Longer contact time increases minoxidil absorption, but doesn't affect metabolism.

research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

53 citations , May 1990 in “Journal of Dermatology”

Minoxidil speeds up hair growth in rats without prolonging growth phase.

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

70 citations , April 1990 in “Journal of The American Academy of Dermatology”

Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.

research Influence of Tretinoin on the Percutaneous Absorption of Minoxidil from an Aqueous Topical Solution

30 citations , April 1990 in “Clinical Pharmacology & Therapeutics”

Tretinoin cream boosts minoxidil absorption, possibly improving hair loss treatment.

research Uptake Kinetics and the Effect of Minoxidil on Human Keratinocyte Cultures

8 citations , April 1990 in “PubMed”

Minoxidil helps hair growth by prolonging cell division in skin cells.

research Sulfation of Minoxidil in Keratinocytes and Hair Follicles

19 citations , October 1989 in “PubMed”

Minoxidil helps hair growth by being sulfated in hair follicles.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations , March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Patch Testing Procedures in Patients Suffering from Suspected Allergic Contact Dermatitis to Minoxidil

4 citations , January 1989

Allergic reactions to minoxidil may be due to the propylene glycol it is mixed with, not the minoxidil itself.

research 3 Percent Topical Minoxidil Compared With Placebo for the Treatment of Chronic Severe Alopecia Areata

26 citations , June 1988 in “PubMed”

3% topical minoxidil is ineffective for severe chronic alopecia areata.

research Does Topical Minoxidil Increase Skin Blood Flow? A Laser Doppler Flowmetry Study

6 citations , January 1988 in “PubMed”

Topical minoxidil does not increase skin blood flow.

research Allergic Contact Dermatitis from Minoxidil

13 citations , January 1988 in “Contact Dermatitis”

Some patients using Minoxidil for baldness developed allergic skin reactions.

research Response to Minoxidil in Severe Alopecia Areata Correlates With T Lymphocyte Stimulation

13 citations , December 1987 in “British Journal of Dermatology”

Increased T cell activity may predict hair regrowth success with minoxidil in severe alopecia areata.

research Topical Minoxidil Therapy for Androgenetic Alopecia

20 citations , November 1987 in “Archives of Dermatology”

The document concludes that topical minoxidil therapy is safe and effective in promoting hair growth for male pattern baldness.

research Topical Minoxidil Sensitization in Androgenic Alopecia

14 citations , July 1987 in “Contact Dermatitis”

A small percentage of minoxidil users may develop an allergic skin reaction.

research Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment

57 citations , July 1987 in “Journal of The American Academy of Dermatology”

Stopping minoxidil treatment resumes balding; continuous use needed for results.

research Dose-Response Study of Topical Minoxidil in Male Pattern Alopecia

24 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil 1% and 2% best promote hair growth and may prevent hair loss.

research Hypertrichosis and Congenital Anomalies Associated With Maternal Use of Minoxidil

36 citations , March 1987 in “Pediatrics”

Minoxidil use during pregnancy can cause excessive hair growth and multiple birth defects in the baby.

research Androgenetic Alopecia: Treatment Results with Topical Minoxidil

39 citations , March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.

research Androgenetic Alopecia Treated With Topical Minoxidil

32 citations , March 1987 in “Journal of The American Academy of Dermatology”

Using minoxidil on balding men's scalps can increase hair growth, according to a 12-month study.

research Use of Topical Minoxidil in the Treatment of Male Pattern Baldness

53 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil effectively regrows hair in male pattern baldness.

research Long-Term Efficacy of Topical Minoxidil in Male Pattern Baldness

41 citations , March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil effectively treats male pattern baldness and prevents hair loss.

research Topical Minoxidil in Early Androgenetic Alopecia

44 citations , March 1987 in “Journal of The American Academy of Dermatology”

Using minoxidil on balding scalps can stimulate hair regrowth and increase blood flow. It's an effective treatment for early hair loss.

research Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia

67 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair growth and prevents hair loss in androgenetic alopecia. It's safe and effective.

research Immunohistochemical Characterization of the Cellular Infiltrate in Severe Alopecia Areata Before and After Minoxidil Treatment

31 citations , January 1987 in “Dermatology”

Minoxidil helps hair regrowth in severe alopecia areata by changing immune cell behavior.

research Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster

26 citations , January 1987 in “Archives of Dermatology”

Topical minoxidil does not block androgen effects.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , January 1987 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up

34 citations , January 1987 in “Dermatology”

Topical minoxidil effectively and safely treats extensive alopecia areata but doesn't change its course.

research Biochemical Mechanisms by Which Minoxidil Sulfate Influences Mammalian Cells

13 citations , January 1987 in “Dermatology”

Minoxidil sulfate relaxes blood vessels by increasing potassium permeability.

research Topical Tretinoin for Hair Growth Promotion

73 citations , October 1986 in “Journal of the American Academy of Dermatology”

Tretinoin may help hair growth and works better when combined with minoxidil.

research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

58 citations , July 1986 in “Journal of The American Academy of Dermatology”

Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.

research The Stumptailed Macaque as a Model for Baldness: Effects of Minoxidil

18 citations , April 1986 in “International Journal of Cosmetic Science”

Minoxidil promotes hair regrowth in early baldness stages and prevents baldness in non-bald scalps.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

Higher minoxidil concentration (5%) works better for severe hair loss, with most patients seeing regrowth in 48-60 weeks.

research Percutaneous Absorption of Minoxidil in Humans

52 citations , February 1985 in “Archives of Dermatology”

Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations , December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

research Minoxidil: Right Atrial Cardiac Pathology in Animals and Humans

35 citations , August 1980 in “Circulation”

Minoxidil may cause heart issues in animals and humans.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

Related Research

8 / 8 results

research Does Microneedling with 5% Minoxidil Offer Added Advantage for Treatment of Androgenetic Alopecia Compared to Use of Topical 5% Minoxidil Alone?

March 2020 in “International Journal of Research in Medical Sciences”

Microneedling with 5% minoxidil works better for hair loss than using 5% minoxidil alone.

research Male Androgenetic Alopecia Treated with Microneedling Alone or Associated with Injectable Minoxidil by Microinfusion of Drugs into the Skin

5 citations , January 2016 in “Surgical and Cosmetic Dermatology”

research Finasteride in the Treatment of Female Pattern (Androgenic) Alopecia: A Case Report and Review of the Literature

6 citations , August 2012 in “PubMed”

Finasteride may effectively treat female pattern hair loss.

research Alopecia Secondary to Mesotherapy

49 citations , July 2009 in “Journal of the American Academy of Dermatology”

Some people experienced hair loss after mesotherapy treatments for hair loss.

A Quantitative Hair Growth Assessment in Androgenetic Alopecia After Application of Two Cosmetic Lotions Versus 2% Topical Minoxidil

research A Quantitative Hair Growth Assessment in Androgenetic Alopecia After Application of Two Cosmetic Lotions Versus 2% Topical Minoxidil

March 2005 in “Journal of The American Academy of Dermatology”

Two cosmetic lotions improved hair growth and had better cosmetic effects than 2% minoxidil.

research Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls

63 citations , April 2003 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil use increases facial hair growth in females, more in older users.

research Hair Growth Therapies for Androgenetic Alopecia

June 1996 in “Archives of Dermatology”

Minoxidil, tretinoin, and finasteride may help hair regrowth in mild to moderate androgenetic alopecia.

research Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

55 citations , February 1985 in “Archives of Dermatology”

Minoxidil applied twice daily can help regrow hair in some people with hereditary baldness, with no serious side effects.