Minoxidil: Right Atrial Cardiac Pathology in Animals and Humans

This study found that none of the nine minoxidil-treated autopsy cases showed cardiac pathology attributable to minoxidil, suggesting no direct link between the drug and specific human cardiac lesions.

This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.

This study observed that minoxidil induced myocardial necroses and hemorrhages in beagle dogs and miniature swine, with greater severity seen in dogs.

This study found that long-term minoxidil treatment, despite improving hemodynamics and left ventricular function, was associated with more frequent clinical events and a poorer clinical course in patients with chronic left ventricular failure.