A Comparative Study of Minoxidil-Induced Myocardial Lesions in Beagle Dogs and Miniature Swine

    January 1989 in “ Toxicologic Pathology ”
    Eugene H. Herman, Victor J. Ferrans, Robert H. Young, Tibor Balazs
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    TLDR A study found that minoxidil can damage the hearts of dogs and pigs, cautioning its use in humans.
    A study compared the effects of minoxidil on the hearts of beagle dogs and miniature swine and found that both animals developed heart damage, with higher doses causing more severe damage. The study suggests caution when using minoxidil in humans due to its potential cardiac effects. The damage was less severe in beagle dogs when given antihistaminic agents beforehand, and calcium channel blockers were effective in reducing the severity of the lesions in both species. Further research is needed to fully understand the impact of minoxidil on the heart.
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