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Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?

research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

6 citations , April 2014 in “European journal of medicinal chemistry”

This study found that several newly synthesized dihydrobenzopyran compounds inhibited insulin secretion and had vasorelaxant activity, with some more potent than reference KATP channel activators, though compound 21 functioned as a Ca2+ entry blocker.

research Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice

November 2025 in “Biomedicine & Pharmacotherapy”

This study found that administering calcium blockers verapamil or nimodipine significantly preserved auditory function and hair cell survival in Cx26-cKO mice, suggesting potential protective effects for other inner ear disorders.

research Skin Conditions in Figure Skaters, Ice-Hockey Players and Speed Skaters

48 citations , October 2011 in “Sports Medicine”

This review covers dermatological conditions experienced by ice-skating athletes due to cold exposure, infections, and inflammation, providing no new clinical findings and emphasizing diagnosis and treatment strategies.

research A Comparative Study of Minoxidil-Induced Myocardial Lesions in Beagle Dogs and Miniature Swine

34 citations , January 1989 in “Toxicologic Pathology”

This study observed that minoxidil induced myocardial necroses and hemorrhages in beagle dogs and miniature swine, with greater severity seen in dogs.

research The necessity of investigations to clarify sex and racial disparities in pathophysiology of Long COVID

January 2024 in “Hypertension research”

More research is needed to understand sex and racial differences in long COVID.

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community Could Minoxidil also be effective with Raynauds Syndrome

6 upvotes 1 year ago

The conversation discusses using oral Minoxidil, a vasodilator, for both Raynaud's Syndrome and hair loss. It also inquires about other hair loss treatments that improve blood flow.

community We don't talk about vitamin E enough

63 upvotes 7 years ago

A user shared that taking vitamin E, specifically tocotrienols, seemed to reduce their hair shedding, and they are also using finasteride, minoxidil, and derma rolling for hair loss. Another user cautioned against high doses of vitamin E due to potential health risks.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community Why don’t more people use hair fibers?

in Product 527 upvotes 10 months ago

Hair fibers can effectively cover thinning hair when used with minoxidil and hairspray but require daily application and can be inconvenient in certain conditions. Some users prefer treatments like finasteride, dutasteride, microneedling, or wigs due to the maintenance and limitations of hair fibers.

community What 3 months without fin& min does😔

in Progress Pictures 261 upvotes 1 year ago

Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

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