The Metabolites of Bifidobacterium Longum BB536 Alleviate DHT-Damaged Human Dermal Papilla Cells by Activating WNT/β-Catenin Signaling

    August 2024 in “ Food Bioscience
    Yiming Ren, Liang Li
    TLDR Bifidobacterium longum BB536 metabolites may help treat hair loss by repairing and promoting hair cell growth.
    The study investigated the potential of Bifidobacterium longum BB536 metabolites to treat hair loss by using its Cell-Free Supernatant (CFS) on dihydrotestosterone (DHT)-damaged human dermal papilla cells (HDPCs). Results showed that 10% CFS treatment for 24 hours significantly promoted HDPC proliferation, repaired cell damage, accelerated the cell cycle, and increased VEGF secretion. CFS also reduced apoptosis and pro-inflammatory factors while improving alkaline phosphatase activity. The metabolites activated the Wnt/β-catenin signaling pathway, increasing protein expressions like Wnt10b, β-catenin, and LEF-1, and inhibiting DHT-induced negative feedback factors DKK1 and GSK-3β. These effects are comparable to minoxidil, suggesting that B. longum BB536 metabolites could be a safe new treatment for androgenic alopecia.
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