Synergizing Biomaterials And Cellular Molecular Pathways: A New Frontier In Hair Follicle Generation

    October 2025 in “ Journal of Translational Medicine
    Amir Bajouri, Nasser Aghdami, Mohammad Ali Nilforoushzadeh
    TLDR Combining biomaterials and cell pathways can improve hair follicle regeneration.
    This literature review discusses the challenges and advancements in generating fully functional hair follicles for clinical applications. It explores the molecular and cellular mechanisms involved in hair follicle development and cycling, focusing on key signaling pathways. The review highlights promising biomaterials and regenerative strategies, including hair micropatterning models, hair follicle organoids, 3D printing of microneedle arrays, microfollicle generation, and biofabrication technologies. It emphasizes the importance of integrating stem cell research and tissue engineering to optimize hair follicle regeneration and improve therapeutic outcomes.
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