Advances and Applications of Biomimetic Biomaterials for Endogenous Skin Regeneration

The document discusses the potential of biomimetic biomaterials in enhancing endogenous skin regeneration, which is crucial for wound healing by leveraging the skin's natural regenerative abilities and minimizing risks like immune rejection. Current biomaterials are limited in their ability to mimic complex tissue structures and manage the microenvironment. Advances in biomimetic materials focus on structural and functional mimicry, regulation of physiological processes, and biophysical property design. Emerging techniques such as in situ reprogramming, flexible electronic skin, artificial intelligence, single-cell sequencing, and spatial transcriptomics are highlighted for their potential contributions. The review also addresses the future prospects and challenges in the clinical application of these biomaterials for effective skin regeneration.