Cocktail Cell-Reprogrammed Hydrogel Microspheres Achieving Scarless Hair Follicle Regeneration

    January 2024 in “ Advanced Science ”
    Shuaifei Ji, Yingying Li, Lei Xiang … Xiaoyan Sun
    Studysummary In this study, researchers used a chemical cocktail and hydrogel microspheres to successfully guide fibroblasts into dermal papilla cells, promoting wound healing and in situ hair follicle regeneration while reducing scar formation, in both in vitro and in vivo experiments.
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    Research cited in this study 18

    1. Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds With Endoplasmic Reticulum Stress-Relieving Properties For Promoted Scarless Wound Healing ACS Applied Materials & Interfaces · 2023
    2. Anagen Hair Follicles Transplanted Into Mature Human Scars Remodel Fibrotic Tissue npj regenerative medicine · 2023
    3. A Volar Skin Excisional Wound Model for In Situ Evaluation of Multiple-Appendage Regeneration and Innervation Burns & Trauma · 2023
    4. Biofabrication of Human Skin with Its Appendages Advanced Healthcare Materials · 2022
    5. Tideglusib Promotes Wound Healing in Aged Skin by Activating PI3K/Akt Pathway Stem Cell Research & Therapy · 2022
    6. Melatonin Increases Growth Properties in Human Dermal Papilla Spheroids by Activating AKT/GSK3β/β-Catenin Signaling Pathway PeerJ · 2022
    7. Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads Journal of Bioscience and Bioengineering · 2022
    8. Direct Reprogramming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules International Journal of Molecular Sciences · 2022
    9. Fibroblasts in Scar Formation: Biology and Clinical Translation Oxidative Medicine and Cellular Longevity · 2022
    10. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    11. Wound Healing: Cellular Mechanisms and Pathological Outcomes Open Biology · 2020
    12. Pre-Aggregation of Scalp Progenitor Dermal and Epidermal Stem Cells Activates the WNT Pathway and Promotes Hair Follicle Formation In Vitro and In Vivo Systems Stem Cell Research & Therapy · 2019
    13. Ginsenoside Rb1 Promotes the Growth of Mink Hair Follicle via PI3K/AKT/GSK-3β Signaling Pathway Life Sciences · 2019
    14. Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction Scientific Reports · 2016
    15. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    16. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    17. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    18. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008