Melatonin Increases Growth Properties in Human Dermal Papilla Spheroids by Activating AKT/GSK3β/β-Catenin Signaling Pathway

May 2022 in “ PeerJ ”

Sowon Bae, Yoo Gyeong Yoon, Ji Yea Kim, In-Chul Park, Sungkwan An, Jae Ho Lee, Seunghee Bae

melatonin human dermal papilla cells MTNR1B 3D sphere culture WNT/β-catenin signaling pathway AKT/GSK3β/β-Catenin signaling pathway hair growth regulation proliferation signaling hair growth 3D culture WNT signaling AKT signaling

Studysummary This study suggests that melatonin promotes hair growth-related properties in DP cells by activating the AKT/GSK3β/β-catenin signaling pathway through melatonin receptors in a 3D spheroid culture system.

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The study found that melatonin increases the growth properties of human dermal papilla (DP) cells, which are crucial for hair growth. Melatonin receptors, particularly MTNR1B, were found to be more highly expressed in these cells, especially in 3D sphere culture conditions. Melatonin treatment increased the size of human dermal papilla spheroids by up to 20.86% and enhanced the expression of genes that regulate hair growth. It also activated the WNT/β-catenin and AKT/GSK3β/β-Catenin signaling pathways, key regulators of hair-inductive properties. The study concludes that melatonin could potentially regulate hair growth by influencing the proliferation and signaling of DP cells.

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