Anagen Hair Follicles Transplanted Into Mature Human Scars Remodel Fibrotic Tissue

    January 2023 in “ npj regenerative medicine ”
    Magdalena Plotczyk, Francisco Jiménez, Summik Limbu … Claire A. Higgins
    Studysummary This study found that transplanting hair follicles into human scars may remodel fibrotic tissue and reduce scarring by altering collagen structure and decreasing pro-fibrotic factors.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 19

    1. Treatment of Postsurgical Scalp Scar Deformity Using Follicular Unit Hair Transplantation BioMed Research International · 2019
    2. Subpopulations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Using Skin Substitutes in the Clinic British Journal of Dermatology · 2017
    3. The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine ACS biomaterials science & engineering · 2017
    4. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    5. Association Between Scalp Laxity, Elasticity, and Glidability and Donor Strip Scar Width in Hair Transplantation and a New Elasticity Measuring Method Dermatologic Surgery · 2016
    6. Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions Advances in wound care · 2016
    7. Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells Experimental Dermatology · 2015
    8. Follicular Unit Transplantation for the Treatment of Secondary Cicatricial Alopecia Plastic surgery · 2014
    9. Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice Experimental Dermatology · 2014
    10. Follicular Unit Transplantation for the Treatment of Secondary Cicatricial Alopecia Plastic surgery (Oakville. Print) · 2014
    11. Hair Follicle Transplantation on Scar Tissue Journal of Craniofacial Surgery · 2013
    12. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    13. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    14. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    15. Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation Journal of Investigative Dermatology Symposium Proceedings · 2001
    16. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    17. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000
    18. Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle Archives of Dermatological Research · 1998
    19. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996