Advances in Hair Restoration: Wnt/Beta-Catenin Pathway and Stem Cell-Based Therapies

November 2021 in “ Current Otorhinolaryngology Reports ”

Natalie A. Krane, Elena Christofides, Yael Ptachewich Halaas

TLDR New treatments for hair loss could involve using stem cells and a process called the Wnt/beta-catenin pathway to stimulate hair growth.

The document "Advances in Hair Restoration" discusses the potential of the Wnt/beta-catenin signaling pathway and stem cell-based therapies in treating hair loss and promoting hair regeneration. The Wnt/beta-catenin pathway plays a key role in hair follicle development and skin stem cell differentiation, making it a potential target for hair loss therapies. Stem cell-based therapies, especially those using adipose-derived stem cells, have shown promise in treating alopecia by stimulating hair growth, possibly through increased growth factor secretion. The paper also discusses the potential of using mesenchymal stem cells from bone marrow and umbilical cord in hair multiplication. Additionally, the secretome of human mesenchymal stem cells could potentially be used as a cell-free therapeutic strategy for neurodegenerative disorders, which may also have implications for hair loss treatments.

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Research cited in this study

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