Dissecting the bulge in hair regeneration

February 2012 in “ Journal of Clinical Investigation ”

Peggy Myung, Mayumi Ito

TLDR Stem cells in hair follicles are diverse and change throughout the hair cycle.

The document reviewed the role of stem cells in the adult hair follicle, highlighting their heterogeneity and dynamic nature throughout the hair cycle. It discussed recent findings on the interactions between different types of stem cells, such as epithelial and melanocyte stem cells, within the hair follicle. The review aimed to provide a foundational understanding of the development, organization, and regeneration of hair follicle stem cells, serving as a reference for integrating emerging studies on the molecular mechanisms regulating these cells.

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Research cited in this study

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research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

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Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

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Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

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Basal cell carcinomas in mice can start from hair follicle stem cells and other skin cell types, depending on signaling levels.

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Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

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Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

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Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

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503 citations , May 2009 in “Cell stem cell”

Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.

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835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

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Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

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MTS24 marks a new type of skin cell that helps hair growth and repair.

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1279 citations , November 2005 in “Nature Medicine”

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Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

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The K15 promoter effectively targets stem cells in the hair follicle bulge.

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561 citations , April 2003 in “Journal of Investigative Dermatology”

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Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

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Tcf3 and Lef1 are key in deciding skin stem cell roles.

Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

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Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

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Hair follicle stem cells can form both hair follicles and skin.

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Hair follicle biology advancements may lead to better hair growth disorder treatments.

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Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.

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Hair growth and pigmentation in mice involve specific stages crucial for research.

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