Image

    Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia

    A. Premanand, B. Reena Rajkumari
    Studysummary This review describes the molecular interactions between androgens and Wnt/ß-catenin signaling in androgenetic alopecia but reports no new experimental or clinical findings; the authors discuss potential Wnt/ß-catenin-targeted treatments for hair growth.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on link.springer.com →
    Discuss this study in the Community →

    Research cited in this study 56

    1. Getting to the Core of the Dermal Papilla Journal of Investigative Dermatology · 2017
    2. The Negative Regulator CXXC5: Making WNT Look a Little Less Disheveled Journal of Investigative Dermatology · 2017
    3. NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    4. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2017
    5. Therapeutic Advances in Trichology Actas Dermo-Sifiliográficas · 2017
    6. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    7. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    8. Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment Fitoterapia · 2016
    9. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    10. A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women JAMA Dermatology · 2016
    11. Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us? Experimental Dermatology · 2016
    12. Bad Hair Day: Testosterone and Wnt Signaling Journal of Investigative Dermatology · 2015
    13. In Silico Prediction of Prostaglandin D2 Synthase Inhibitors from Herbal Constituents for the Treatment of Hair Loss Journal of Ethnopharmacology · 2015
    14. Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling Journal of Investigative Dermatology · 2015
    15. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    16. Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer Journal of The European Academy of Dermatology and Venereology · 2014
    17. Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis Journal of Dermatology · 2014
    18. Increased DHT Levels in Androgenic Alopecia Selected to Protect Men from Prostate Cancer Medical Hypotheses · 2014
    19. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    20. Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss Archives of Dermatological Research · 2013
    21. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    22. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    23. The Basic Science of Hair Biology Dermatologic Clinics · 2012
    24. Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling Life Sciences · 2012
    25. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    26. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    27. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    28. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    29. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    30. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    31. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    32. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    33. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    34. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    35. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    36. Gerontobiology of the Hair Follicle 2010
    37. Molecular Basis of Androgenetic Alopecia Springer eBooks · 2010
    38. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    39. Androgens and Hair Growth Dermatologic Therapy · 2008
    40. Baldness, Benign Prostate Hyperplasia, Prostate Cancer, and Androgen Levels The Aging Male · 2008
    41. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    42. Men With Kennedy Disease Have a Reduced Risk of Androgenetic Alopecia British Journal of Dermatology · 2007
    43. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    44. The Hair Cycle Journal of Cell Science · 2006
    45. Expression of Androgen Receptor Coactivator ARA70/ELE1 in Androgenic Alopecia Journal of Cutaneous Pathology · 2005
    46. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    47. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    48. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    49. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    50. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    51. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    52. The Hair Follicle: A Paradoxical Androgen Target Organ Hormone Research in Paediatrics · 2000
    53. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    54. Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne Journal of Cutaneous Medicine and Surgery · 1998
    55. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    56. Androgenetic Alopecia Springer eBooks · 1996

    Related research 8

    1. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    2. Minoxidil to Treat Androgenetic Alopecia in Men and Women: What Is It and How Does It Work? American Journal of Medicine and Medical Sciences · 2014
    3. Relation Between Dermal Papilla Cells and Androgenetic Alopecia International Journal of Dermatology and Venereology · 2010
    4. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    5. Male Androgenetic Alopecia The Journal of Men's Health & Gender · 2004
    6. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    7. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    8. Clinical Updates in Hair Dermatologic Clinics · 1997