Human Hair Regeneration Using Organoids and Hair-On-Chip Technologies

    January 2026 in “ Lab on a Chip ”
    I. Ahmed, Abbas Shafiee
    Studysummary In this perspective, recent advances in regenerative medicine, including bioartificial substitutes and engineered in vitro platforms, are reviewed for their potential to restore human hair follicles, highlighting new technologies like 3D printing, hair-on-a-chip models, and stem cell-derived organoids.
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    Research cited in this study 42

    1. Generating Skin-Derived Precursor-Like Cells From Human-Induced Pluripotent Stem Cell-Derived Skin Organoids Experimental Dermatology · 2024
    2. The Empowering Influence of Air-Liquid Interface Culture on Skin Organoid Hair Follicle Development Burns & Trauma · 2024
    3. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    4. Immune Niches for Hair Follicle Development and Homeostasis Frontiers in physiology · 2024
    5. Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device Advanced healthcare materials/Advanced Healthcare Materials · 2024
    6. Optimization of Hair Follicle Spheroids for Hair-On-A-Chip Biomaterials Science · 2024
    7. Design and Proof-of-Concept of Single Robotic Hair Transplant Mechanisms for Both Harvest and Implant of Hair Grafts Computational and Structural Biotechnology Journal · 2023
    8. Skin-On-A-Chip Strategies For Human Hair Follicle Regeneration Experimental Dermatology · 2022
    9. Biofabrication of Human Skin with Its Appendages Advanced Healthcare Materials · 2022
    10. In Vitro and Ex Vivo Hair Follicle Models to Explore Therapeutic Options for Hair Regeneration Stem cell biology and regenerative medicine · 2022
    11. The Dermal Papilla and Hair Follicle Regeneration: Engineering Strategies to Improve Dermal Papilla Inductivity Stem cell biology and regenerative medicine · 2022
    12. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    13. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021
    14. Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine Scientific Reports · 2021
    15. Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia International Journal of Molecular Sciences · 2020
    16. Microscopy-Guided Laser Ablation for the Creation of Complex Skin Models with Folliculoid Appendages Bioengineering & translational medicine · 2020
    17. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    18. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    19. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    20. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    21. Reconstructed Human Skin Shows Epidermal Invagination Towards Integrated Neopapillae Indicating Early Hair Follicle Formation In Vitro Journal of Tissue Engineering and Regenerative Medicine · 2020
    22. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    23. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    24. TSA Restores Hair Follicle-Inductive Capacity of Skin-Derived Precursors Scientific Reports · 2019
    25. Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration PubMed · 2019
    26. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    27. Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models Experimental Dermatology · 2018
    28. Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018
    29. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    30. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    31. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    32. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    33. Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells Scientific Reports · 2017
    34. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    35. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    36. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction Journal of Investigative Dermatology · 2016
    37. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    38. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    39. Regenerative Medicine and Hair Loss: How Hair Follicle Culture Has Advanced Our Understanding of Treatment Options for Androgenetic Alopecia Regenerative Medicine · 2013
    40. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    41. Skin And Hair On-A-Chip: In Vitro Skin Models Versus Ex Vivo Tissue Maintenance With Dynamic Perfusion Lab on a Chip · 2013
    42. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009