The Dermal Papilla and Hair Follicle Regeneration: Engineering Strategies to Improve Dermal Papilla Inductivity

    January 2022 in “ Stem cell biology and regenerative medicine ”
    Nikolaos Pantelireis, Gracia Goh, Carlos Clavel
    TLDR Improving dermal papilla cells can help regenerate hair follicles.
    The document reviews engineering strategies to enhance the inductive properties of dermal papilla cells (DPCs) for hair follicle regeneration. Key findings include the activation of DPCs by extracellular vesicles from mesenchymal stem cells, promoting hair follicle transition from telogen to anagen phases in mice, and the role of adenosine in stimulating DPC growth and prolonging the anagen phase. Hypoxia and glucose metabolism improve hair inductivity of DPCs, while WNT and BMP signaling, and interactions between dermal papilla and dermal sheath cells, are crucial for maintaining hair-inducing activity. Various culture techniques, such as spheroid formation and co-culturing with keratinocytes, are discussed to restore or enhance DPCs' hair-inductive capabilities.
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