Hair Growth-Promoting Effects of Astragalus Sinicus Extracts in Human Follicle Dermal Papilla Cells

    January 2025 in “ Cosmetics
    Chae Young Jeon, Min Young Go, In-Kyung Kim, Myung-Rye Park, Han Cheol Lee, Youn-Kyu Kim, Dong Wook Shin
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    TLDR Astragalus sinicus extracts may help promote hair growth and treat hair loss.
    The study explores the effects of Astragalus sinicus extracts (ASEs) on human follicle dermal papilla cells (HFDPCs) damaged by dihydrotestosterone (DHT), a factor in hair loss. ASEs were shown to enhance cell viability and proliferation, promote wound healing, and increase alkaline phosphatase activity. They also reduced reactive oxygen species levels, improved mitochondrial function, and increased ATP levels. Furthermore, ASEs activated the ERK/AKT and Wnt/β-catenin signaling pathways, which are crucial for hair growth. These findings suggest that ASEs could be a promising natural treatment for hair loss, based on experiments conducted with three independent trials.
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