AP Collagen Peptides (APCPs) Promote Hair Growth by Activating the GSK-3β/β-Catenin Pathway and Improve Hair Condition

AP collagen peptides (APCPs) promote hair growth by increasing the proliferation of human dermal papilla cells (hDPCs) and human outer root sheath cells (hORSCs), and by stimulating the secretion of growth factors such as IGFBP-6, PDGF-AB, PIGF, and VEGF. APCPs activate the GSK-3β/β-catenin signaling pathway, as evidenced by enhanced phosphorylation of Akt, GSK-3β, and β-catenin. Ex vivo and in vivo studies showed that APCPs promote hair follicle elongation, induce new hair shafts, and transition hair from the telogen to anagen phase, resulting in increased hair growth. Additionally, APCPs improve hair thickness, amino acid content, and roughness, suggesting their potential as a food supplement for preventing hair loss and maintaining hair health.