Low Molecular Weight Collagen Peptide Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling Pathway

September 2023 in “ Journal of microbiology and biotechnology ”

Yu Jin Kim, Jung Ok Lee, Jung Min Lee, Mun-Hoe Lee, Hyeong-Min Kim, Haerim Chung, Do-Un Kim, Jin‐Hee Lee, Beom Joon Kim

low molecular weight collagen peptide LMWCP hair growth Wnt/GSK-3β/β-catenin signaling pathway cell proliferation mitochondrial potential human dermal papilla cells hair follicles oral administration hair growth-related proteins hair growth-related genes collagen peptide Wnt signaling pathway dermal papilla cells

TLDR A type of collagen helps hair grow by boosting cell growth and activating a specific hair growth pathway.

The study investigated the effects of low molecular weight collagen peptide (LMWCP) on hair growth and found that LMWCP promotes hair growth by enhancing cell proliferation, mitochondrial potential, and secretion of hair growth-related factors in human dermal papilla cells. It also increased the formation of new hair follicles in a dose-dependent manner and upregulated key proteins and genes in the Wnt/GSK-3β/β-catenin signaling pathway. Additionally, oral administration of LMWCP in mice significantly stimulated hair growth and increased the expression of hair growth-related proteins and genes. These results suggest that LMWCP could be a potential treatment for promoting hair growth by activating the Wnt/β-catenin signaling pathway.

View this study on jmb.or.kr →

Discuss this study in the Community →

Research cited in this study

25 / 25 results

research Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism

7 citations, November 2022 in “Communications biology”

Keratin injections can promote hair growth by affecting hair-forming cells and tissue development.

Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

research Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations, January 2022 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.

research TGF-β2 and Collagen Play Pivotal Roles in the Spheroid Formation and Anti-Aging of Human Dermal Papilla Cells

11 citations, August 2021 in “Aging”

Collagen and TGF-β2 help maintain hair cell shape and youthfulness.

research Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in In Vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures

10 citations, August 2021 in “Frontiers in cell and developmental biology”

Scientists made structures that look like human hair follicles using stem cells, which could help grow hair without using actual human tissue.

research Getting Under the Skin of Hair Aging: The Impact of the Hair Follicle Environment

20 citations, May 2020 in “Experimental Dermatology”

Aging scalp skin contributes to hair aging and loss, and more research is needed to develop better hair loss treatments.

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations, January 2020 in “Skin Pharmacology and Physiology”

The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.

research Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

13 citations, December 2019 in “Nutrients”

An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.

research Physiopathology and Current Treatments of Androgenetic Alopecia: Going Beyond Androgens and Anti-Androgens

45 citations, August 2019 in “Dermatologic Therapy”

Hair loss treatments work better with lifestyle changes.

research Overexpression of Alkaline Phosphatase Improves the Hair-Inductive Capacity of Cultured Human Dermal Papilla Spheres

13 citations, July 2019 in “Journal of Dermatological Science”

Increasing alkaline phosphatase in human skin cells helps to grow more hair.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations, July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

research Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration

17 citations, February 2019 in “PubMed”

Stem cells can help regenerate hair follicles.

research Generation of Trichogenic Adipose-Derived Stem Cells by Expression of Three Factors

12 citations, August 2018 in “Journal of Dermatological Science”

Scientists made stem cells that can grow hair by adding three specific factors to them.

research Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells

42 citations, February 2018 in “International Journal of Molecular Sciences”

Minoxidil boosts hair growth by triggering growth factor release from specific stem cells.

research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

40 citations, March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Growing hair follicles have high mitochondrial activity and ROS in specific regions, aiding hair formation.

research Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review

32 citations, July 2016 in “PubMed”

5-alpha reductase inhibitors are generally safe but can cause sexual side effects and require patient education on risks.

research 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment

69 citations, December 2011 in “Journal of Ethnopharmacology”

Some Thai plants, especially Carthamus tinctorius, could help prevent hair loss and promote hair growth without adverse effects.

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

128 citations, October 2011 in “Development”

Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations, August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension

74 citations, May 2004 in “Journal of Clinical Hypertension”

Minoxidil effectively treats severe hypertension, but watch for side effects.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations, February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research The Biology of Hair Follicles

1113 citations, August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations, October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations, October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research The Secret Life of the Hair Follicle

745 citations, February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.