(Neuro-)endocrinology of epithelial hair follicle stem cells

    Ralf Paus, Petra C. Arck, Stephan Tiede
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    TLDR Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
    The 2008 document reviews the complex hormonal and neuroendocrine mechanisms that regulate hair follicle epithelial stem cells (HFeSCs), which are essential for hair growth and pigmentation. It emphasizes the need for more research to understand the specific endocrine controls of HFeSCs. The review discusses the roles of various hormones, neuropeptides, neurotransmitters, and neurotrophins in HFeSC biology, including glucocorticoids, vitamin D, and thymic hormones, and their potential impact on hair growth disorders. It also explores the expression of genes and gene products in HFeSCs, such as insulin-like growth factor binding proteins, which may influence hair follicle cycling and stem cell maintenance. The document suggests that further understanding of these mechanisms could lead to new treatments for hair-related conditions and contribute to regenerative medicine.
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