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GlossaryHair Follicle Epithelial Stem Cells (HFeSCs)

specialized cells that regenerate and produce new hair

Hair Follicle Epithelial Stem Cells are specialized cells located in the hair follicle that have the ability to regenerate and produce new hair. These cells play a crucial role in the growth cycle of hair, as they can differentiate into various cell types needed for hair formation and repair, making them essential for maintaining healthy hair and potentially treating conditions like alopecia.

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research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

42 citations, March 2008 in “Molecular and Cellular Endocrinology”

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

research PPARγ Signaling Modulation Protects From Hair Follicle Bulge Stem Cell Damage and Cyclophosphamide-Induced Hair Follicle Cytotoxicity

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

PPARγ signaling modulation can protect hair follicle stem cells from chemotherapy-induced damage.

research PPAR-γ Modulation as a Novel Therapeutic Strategy for Scarring Alopecia

April 2018 in “Journal of Investigative Dermatology”

A new treatment using AGED to modulate PPAR-γ shows promise for treating scarring hair loss by protecting and repairing hair follicle cells.

research The PPAR-γ Modulator, N-Acetyl-GED, Protects From Epithelial-Mesenchymal Transition in Human Hair Follicles: Potential Relevance for Scarring Alopecia

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

N-acetyl-GED may help prevent and partially reverse a process that leads to scarring hair loss.

research Cyclical Dermal Micro-Niche Switching Governs the Morphological Infradian Rhythm of Mouse Zigzag Hair

4 citations, August 2023 in “Nature Communications”

Mouse zigzag hair bends form due to a 3-day cycle of changes in hair progenitors and their environment.

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community TDM-105795 phase 2 results are in!

in Research/Science 28 upvotes 9 months ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.