Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons

    October 2018 in “ Aesthetic Plastic Surgery ”
    Gordon H. Sasaki
    Studysummary This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 71

    1. Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial Dermatologic Surgery · 2018
    2. Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2015
    3. The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study Journal of The European Academy of Dermatology and Venereology · 2012
    4. Evidence-Based Treatments for Female Pattern Hair Loss: A Summary of a Cochrane Systematic Review British Journal of Dermatology · 2012
    5. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    6. Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia Dermatologic Surgery · 2012
    7. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    8. Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth Dermatologic Surgery · 2011
    9. Alopecia: Evaluation and Treatment Clinical, Cosmetic and Investigational Dermatology · 2011
    10. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    11. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    12. S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents British Journal of Dermatology · 2010
    13. Stem Cells and the Niche: A Dynamic Duo Cell Stem Cell · 2010
    14. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    15. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    16. Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2009
    17. Complications in Hair Restoration Surgery Oral and Maxillofacial Surgery Clinics of North America · 2009
    18. Understanding and Management of Female Pattern Alopecia Facial Plastic Surgery · 2008
    19. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    20. Female Pattern Hair Loss Springer eBooks · 2008
    21. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    22. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    23. Defining Hair Follicles in the Age of Stem Cell Bioengineering Journal of Investigative Dermatology · 2007
    24. The Current Role of Laser and Light Sources in the Treatment of Male and Female Pattern Hair Loss Journal of Cosmetic and Laser Therapy · 2007
    25. Dietary Supplement Increases Anagen Hair Rate in Women With Telogen Effluvium: Results of a Double-Blind, Placebo-Controlled Trial Therapy · 2006
    26. The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery Plastic and reconstructive surgery/PSEF CD journals · 2006
    27. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    28. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    29. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    30. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    31. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    32. Management of Hair Loss Dermatologic Clinics · 2005
    33. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    34. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    35. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    36. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    37. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    38. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    39. Is Androgenic Alopecia a Result of Endocrine Effects on the Vasculature? Medical Hypotheses · 2003
    40. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    41. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    42. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    43. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    44. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    45. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    46. Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice Journal of comparative neurology · 2002
    47. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    48. Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle Journal of Cutaneous Medicine and Surgery · 2002
    49. The Transcriptional Repressor CDP (Cutl1) Is Essential for Epithelial Cell Differentiation of the Lung and the Hair Follicle Genes & development · 2001
    50. Idiopathic Chronic Telogen Effluvium in Women Der Hautarzt · 2000
    51. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    52. Finasteride and the Hair Cycle Journal of The American Academy of Dermatology · 2000
    53. Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women Journal of Investigative Dermatology Symposium Proceedings · 1999
    54. Diffuse Female Hair Loss: Are Androgens Necessary? British Journal of Dermatology · 1999
    55. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    56. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    57. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    58. Local Injection of Hepatocyte Growth Factor/Scatter Factor Alters Cyclic Growth of Murine Hair Follicles Journal of Investigative Dermatology · 1998
    59. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    60. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    61. Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women Journal of The American Academy of Dermatology · 1996
    62. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    63. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993
    64. The Psychological Effects of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 1992
    65. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991
    66. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    67. Dynamic Ultrastructural Changes of the Connective Tissue Sheath of Human Hair Follicles During the Hair Cycle Archives of Dermatological Research · 1990
    68. Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia Clinics in Dermatology · 1988
    69. Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987
    70. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984
    71. Hypertrichosis Due to Minoxidil British Journal of Dermatology · 1979

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