Immune Cell Regulation of the Hair Cycle

    January 2020 in “ Experimental Dermatology ”
    Etienne C.E. Wang, Claire A. Higgins
    Studysummary This review discusses the role of immune cells in mammalian hair cycle control and highlights their potential relevance to human hair cycling disorders, reporting no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 82

    1. An Important Role of Cutaneous Lymphatic Vessels in Coordinating and Promoting Anagen Hair Follicle Growth PLOS ONE · 2019
    2. Regulatory T-Cells in Alopecia Areata Journal of cutaneous pathology · 2019
    3. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    4. Laser-Assisted Hair Regrowth Plastic and reconstructive surgery. Global open · 2019
    5. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    6. Hair Growth Control by Innate Immunocytes: Perifollicular Macrophages Revisited Experimental Dermatology · 2019
    7. Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia Dermatologic Surgery · 2019
    8. Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lasers in Medical Science · 2019
    9. The Main Cause of Hair Rarefaction in Androgenetic Alopecia: Higher Number and Longer Duration of Kenogen Hairs Skin appendage disorders · 2018
    10. A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth Experimental Dermatology · 2018
    11. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    12. iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
    13. Fractional Non-Ablative Laser-Assisted Drug Delivery Leads to Improvement in Male and Female Pattern Hair Loss Journal of Cosmetic and Laser Therapy · 2018
    14. Novel Therapies for Alopecia Areata: The Era of Rational Drug Development The Journal of Allergy and Clinical Immunology · 2017
    15. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    16. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle Journal of Investigative Dermatology · 2017
    17. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    18. Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors Lasers in Medical Science · 2017
    19. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    20. Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium International Journal of Trichology · 2017
    21. Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2016
    22. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    23. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    24. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    25. Hair Regrowth Through Wound Healing Process After Ablative Fractional Laser Treatment in a Murine Model Lasers in Surgery and Medicine · 2015
    26. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    27. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    28. Effect of Mycophenolic Acid on Proliferation of Dermal Papilla Cells and Induction of Anagen Hair Follicles Clinical and experimental dermatology · 2015
    29. Postpartum Telogen Effluvium Journal of the European Academy of Dermatology and Venereology · 2015
    30. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    31. Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair Experimental Dermatology · 2014
    32. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    33. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    34. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    35. Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation Genes & Development · 2014
    36. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    37. A New Humanized Mouse Model For Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013
    38. Hair-Cycle Changes in Two Patients Taking Tocilizumab Joint Bone Spine · 2013
    39. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    40. Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013
    41. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    42. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    43. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    44. Hair Growth-Promoting Effects of Adiponectin In Vitro Journal of Investigative Dermatology · 2012
    45. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    46. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    47. Histologic Features of Alopecia Areata Other Than Peribulbar Lymphocytic Infiltrates 2011
    48. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    49. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    50. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    51. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    52. Diffuse Hair Loss: Its Triggers and Management Cleveland Clinic Journal of Medicine · 2009
    53. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009
    54. Follicular Streamers (Stelae) in Scarring and Non-Scarring Alopecia Journal of Cutaneous Pathology · 2008
    55. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    56. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    57. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    58. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    59. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    60. The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability Animal genetics · 2006
    61. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    62. Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition Journal of Molecular Medicine · 2005
    63. Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo Journal of Investigative Dermatology · 2004
    64. Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model Journal of Investigative Dermatology · 2002
    65. Telogen Effluvium: Causes, Diagnosis, and Treatment Clinical and Experimental Dermatology · 2002
    66. Kenogen Dermatology · 2002
    67. Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P The FASEB Journal · 2001
    68. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    69. Teloptosis: A Turning Point in Hair Shedding Biorhythms Dermatology · 2001
    70. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    71. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    72. Chronic Telogen Effluvium: Incidence, Clinical and Biochemical Features, and Treatment Archives of Dermatology · 1999
    73. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998
    74. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    75. The Anagen Hair Cycle Induces Systemic Immunosuppression of Contact Hypersensitivity in Mice Cellular Immunology · 1998
    76. Chronic Telogen Effluvium Dermatologic Clinics · 1996
    77. Dermal-Epidermal Interactions: Follicle-Derived Cell Populations in the Study of Hair-Growth Mechanisms ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    78. Telogen Effluvium: An Etiopathogenetic Theory International Journal of Dermatology · 1993
    79. Epidermal Keratinocyte Stem Cells: Their Maintenance and Regulation Seminars in cell biology · 1992
    80. Cutaneous Immunopathology of Androgenetic Alopecia The Journal of the American Osteopathic Association · 1991
    81. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977
    82. Role of Macrophages in Collagen Resorption During Hair Growth Cycle Journal of Ultrastructure Research · 1969

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    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001