Parathyroid Hormone-Related Peptide and the Hair Cycle: Is It the Agonists or the Antagonists That Cause Hair Growth?

    July 2014 in “ Experimental Dermatology ”
    Robert C. Gensure
    Studysummary This study suggests that while PTH rP initially seemed to shorten the hair cycle by transitioning hair follicles from anagen to catagen, more relevant models indicate it ultimately accelerates and stimulates hair growth.
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    Research cited in this study 16

    1. Therapy for Alopecia Areata in Mice Using Parathyroid Hormone Agonists and Antagonists, Linked to a Collagen-Binding Domain Journal of Investigative Dermatology Symposium Proceedings · 2013
    2. Hair Cycle Control by Leptin as a New Anagen Inducer Experimental Dermatology · 2013
    3. Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model Anti-Cancer Drugs · 2013
    4. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    5. Expression and Localization of Artemis Serine 516 Phosphorylation in Human Scalp Skin Experimental Dermatology · 2012
    6. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    7. Treatment for Chemotherapy-Induced Alopecia in Mice Using Parathyroid Hormone Agonists and Antagonists Linked to a Collagen Binding Domain International Journal of Cancer · 2011
    8. Thyroid Hormone Action on Skin Dermato-endocrinology · 2011
    9. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010
    10. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    11. A Topical Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Antagonist Stimulates Hair Growth in Mice Endocrinology · 2006
    12. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    13. Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin Journal of Investigative Dermatology · 2006
    14. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    15. Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2003
    16. Overexpression of Parathyroid Hormone-Related Protein in the Skin of Transgenic Mice Interferes with Hair Follicle Development Proceedings of the National Academy of Sciences · 1994

    Related research 9

    1. Comparison of Ruxolitinib and a Collagen-Targeted PTH-Based Hair Cycle Stimulant on Hair Follicle Counts and Hair Growth in the C3H/HeJ Engrafted Mouse Model of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
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    4. Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain Journal of Investigative Dermatology Symposium Proceedings · 2015
    5. Parathyroid Hormone-Related Peptide and the Hair Cycle: Is It the Agonists or the Antagonists That Cause Hair Growth? Experimental Dermatology · 2014
    6. Disorders of Hair DeckerMed Family Medicine · 2013
    7. Remission of Hair Loss and Induction of Hair Regrowth by Botulinum Neurotoxin A in Mice Toxicon · 2008
    8. Alopecia Journal of the Korean Medical Association · 2002
    9. Animal Models and Culture Methods in the Study of Hair Growth Clinics in dermatology · 2001