Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

The 2006 study explored how Parathyroid Hormone-Related Protein (PTHrP) and the PTH/PTHrP receptor (PPR) influence hair growth and blood vessel formation in the skin of mice. Overexpression of PTHrP led to shorter hair shafts and reduced blood vessel size and number around hair follicles, while mice lacking PTHrP or PPR had increased vascularization. These findings suggest that PTHrP and PPR may directly affect endothelial cells and play a role in inhibiting angiogenesis during the hair cycle, potentially impacting hair follicle development. The study used groups of 3 mice for each time point, 5 samples for histomorphometric analysis, and 6 samples for embryonic day 19 analysis. The research was conducted in accordance with Indiana University's animal care guidelines and was funded by the NIH Grant R01 AR45585, with no conflicts of interest reported.