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GlossaryParathyroid Hormone-related Protein

regulates calcium levels and influences bone development

Parathyroid Hormone-related Protein (PTHrP) is a protein that plays a crucial role in regulating calcium levels in the body, similar to parathyroid hormone (PTH). It is involved in various physiological processes, including the development of bones and the regulation of cellular growth and differentiation. PTHrP is also significant in certain medical conditions, such as hypercalcemia of malignancy, where it can be produced in excess by some types of cancer cells.

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research Parathyroid Hormone-Related Protein in Normal and Neoplastic Canine Tissues: Immunohistochemical Localization and Biochemical Extraction

54 citations , May 1994 in “Veterinary Pathology”

PTHrP is higher in certain dog tumors and may act as a local growth factor.

Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition

research Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition

52 citations , May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Parathyroid hormone-related protein helps control hair growth phases in mice.

research Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

33 citations , May 2006 in “Journal of Investigative Dermatology”

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

research The Parathyroid Hormone-Related Protein as a Regulator of Normal Tissue Functions

4 citations , January 1994 in “Current Opinion in Endocrinology & Diabetes”

PTHrP regulates various normal body functions, including bone development, skin, and muscle function.

research Overexpression of Parathyroid Hormone-Related Protein in the Skin of Transgenic Mice Interferes with Hair Follicle Development

211 citations , February 1994 in “Proceedings of the National Academy of Sciences”

Too much parathyroid hormone-related protein in skin disrupts hair growth in mice.

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