The Role of WNT10B in Physiology and Disease: A 10-Year Update

February 2023 in “ Frontiers in Cell and Developmental Biology ”

Rachel S. Perkins, Rishika Singh, Amy N. Abell, Susan A. Krum, Gustavo A. Miranda‐Carboni

WNT10B WNT signaling skin hair microRNAs long non-coding RNAs

Studysummary This review discusses the expanded understanding of WNT10B's role in various tissues and diseases over the past decade, emphasizing its genetic correlations and potential therapeutic implications, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

WNT10B is a crucial regulator in various physiological and pathological processes, including bone development, cancer, obesity, and hair growth. It activates the WNT/β-catenin signaling pathway, influencing cell differentiation and proliferation. In bone, it promotes osteoblast differentiation and bone mineral density while inhibiting adipocyte differentiation. WNT10B is also involved in immune regulation, influencing T-cell development, and has implications in conditions like periodontal disease and rheumatoid arthritis. It plays a significant role in hair follicle development and cycling, suggesting potential therapeutic applications for alopecia. In cancer, WNT10B acts as an oncogene in over 15 types, with its expression offering potential therapeutic targets. The document highlights the therapeutic potential of WNT10B in bone-related diseases, cancer, and hair growth, emphasizing the need for further research to explore its applications.

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research Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-Catenin in Inner Mongolia Cashmere Goats

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research Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

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This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.

research LncRNA-599547 Contributes to the Inductive Property of Dermal Papilla Cells in Cashmere Goats Through miR-15b-5p/Wnt10b Axis

7 citations , August 2020 in “Animal biotechnology”

This study found that lncRNA-599547 positively regulates the expression of the Wnt10b gene by interacting with miR-15b-5p, enhancing the inductive property of dermal papilla cells in cashmere goats.

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research LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis

13 citations , April 2020 in “Experimental Cell Research”

This study found that knockdown of PCAT1 inhibited hair follicle regeneration in nude mice by disrupting the miR-329/Wnt10b axis and Wnt/β-catenin signaling, highlighting PCAT1's role in promoting follicle regrowth.

research Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation

49 citations , July 2019 in “British Journal of Dermatology”

This study found that Wnt signalling agonists increase and antagonists decrease in human scalp follicles from telogen to early-anagen, with differences from the mouse model suggesting targeted interventions for hair growth disorders.

research Narrowband UVB Treatment Induces Expression of WNT7B, WNT10B, and TCF7L2 in Psoriasis Skin

5 citations , May 2019 in “Archives of Dermatological Research”

This study reported that narrowband UVB treatment significantly increased WNT7B, WNT10B, and TCF7L2 gene expression in lesional skin of psoriasis patients, suggesting these genes may play a role in psoriasis pathogenesis.

research The Balance of BMP6 and WNT10B Regulates the Telogen-Anagen Transition of Hair Follicles

35 citations , February 2019 in “Cell Communication and Signaling”

This study found that BMP6 and Wnt10b competitively regulate the transition between hair follicle growth phases, offering new insights into hair follicle cycling and potential hair loss treatments.

Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

47 citations , October 2016 in “Molecular and Cellular Endocrinology”

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

53 citations , April 2014 in “Experimental Dermatology”

In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.

research Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes

29 citations , January 2013 in “International Journal of Medical Sciences”

This study found that Wnt10b promotes melanocyte maturation and pigmentation in the hair bulbs of mice by activating canonical Wnt signaling.

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research Dermal Papilla Cells Serially Cultured with Wnt-10b Sustain Their Hair Follicle Induction Activity After Transplantation into Nude Mice

22 citations , October 2012 in “Cell Transplantation”

This study found that adding Wnt-10b to the culture medium of dermal papilla cells maintained their ability to induce hair follicles over 100 days in vitro.

1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration

research 1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration

32 citations , July 2012 in “Stem Cells Translational Medicine”

In this study, VD(3) pretreatment increased hair follicle formation in a rat model by promoting dermal papilla cell differentiation, suggesting potential for hair regeneration therapy.

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

77 citations , July 2012 in “Journal of Investigative Dermatology”

The researchers observed that overexpression of Wnt10b in a mouse model can induce hair follicle regeneration by switching follicles from the resting phase to the growth phase via the Wnt-β-catenin signaling pathway.