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GlossaryParathyroid Hormone-related Protein (PTHrP)

regulates calcium levels and influences bone development

Parathyroid Hormone-related Protein (PTHrP) is a protein that plays a crucial role in regulating calcium levels in the body, similar to parathyroid hormone (PTH). It is involved in various physiological processes, including the development of bones and the regulation of cellular growth and differentiation. PTHrP is also significant in certain medical conditions, such as hypercalcemia of malignancy, where it can be produced in excess by some types of cancer cells.

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research Mouse Models with a Disrupted PTHrP Gene or a Disrupted PTH Gene (PTH−/− Mice)

October 2010 in “Bone”

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

research Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

33 citations, May 2006 in “Journal of Investigative Dermatology”

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

research Parathyroid Hormone-Related Peptide and the Hair Cycle: Is It the Agonists or the Antagonists That Cause Hair Growth?

9 citations, July 2014 in “Experimental Dermatology”

PTHRP agonists can stimulate hair growth, especially in damaged follicles, while antagonists may initially increase growth but ultimately inhibit it.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations, January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition

research Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition

52 citations, May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Parathyroid hormone-related protein helps control hair growth phases in mice.

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