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GlossaryParathyroid Hormone-related Protein (PTHrP)

regulates calcium levels and influences bone development

Parathyroid Hormone-related Protein (PTHrP) is a protein that plays a crucial role in regulating calcium levels in the body, similar to parathyroid hormone (PTH). It is involved in various physiological processes, including the development of bones and the regulation of cellular growth and differentiation. PTHrP is also significant in certain medical conditions, such as hypercalcemia of malignancy, where it can be produced in excess by some types of cancer cells.

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research Mouse Models with a Disrupted PTHrP Gene or a Disrupted PTH Gene (PTH−/− Mice)

October 2010 in “Bone”

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

research Parathyroid Hormone-Related Protein in Normal and Neoplastic Canine Tissues: Immunohistochemical Localization and Biochemical Extraction

54 citations , May 1994 in “Veterinary Pathology”

PTHrP is higher in certain dog tumors and may act as a local growth factor.

research Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

33 citations , May 2006 in “Journal of Investigative Dermatology”

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

research Parathyroid Hormone-Related Peptide and the Hair Cycle: Is It the Agonists or the Antagonists That Cause Hair Growth?

9 citations , July 2014 in “Experimental Dermatology”

PTHRP agonists can stimulate hair growth, especially in damaged follicles, while antagonists may initially increase growth but ultimately inhibit it.

research The Parathyroid Hormone-Related Protein as a Regulator of Normal Tissue Functions

4 citations , January 1994 in “Current Opinion in Endocrinology & Diabetes”

PTHrP regulates various normal body functions, including bone development, skin, and muscle function.

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