The Parathyroid Hormone-Related Protein as a Regulator of Normal Tissue Functions
January 1994
in “
Current Opinion in Endocrinology & Diabetes
”
Studysummary This review discusses multiple physiological roles of parathyroid hormone-related protein, such as cartilage mineralization and hair follicle regulation, and reports no new experimental results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The parathyroid hormone-related protein (PTHrP) was initially identified as a factor secreted by cancer cells causing hypercalcemia in malignant tumors. However, research revealed its physiological roles, including regulating chondrogenesis and cartilage mineralization, with its gene deletion being embryonically lethal in homozygotes. PTHrP was expressed in lactating mammary tissue, secreted into milk, and involved in hair follicle function and epidermal keratinocyte differentiation in the skin. It also acted as a local regulator of smooth muscle tone and was proposed to regulate parturition and placental calcium transport. Evidence suggested additional PTHrP receptors beyond the classic parathyroid hormone receptor.
