Comparison of Ruxolitinib and a Collagen-Targeted PTH-Based Hair Cycle Stimulant on Hair Follicle Counts and Hair Growth in the C3H/HeJ Engrafted Mouse Model of Alopecia Areata

    April 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    R.C. Gensure, B. King, S. Sikkink, A. Mardaryev, R. Goforth
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    TLDR A PTH-based treatment improved hair regrowth better than ruxolitinib in a mouse model of hair loss.
    The study compared the effects of a single subcutaneous injection of PTH-CBD and daily oral administration of the JAK inhibitor ruxolitinib on hair regrowth and anagen hair follicle counts in C3H/HeJ mice with alopecia areata over 8 weeks. Results showed that PTH-CBD treatment led to a significant increase in anagen hair follicles (p<0.05) and improved hair regrowth compared to ruxolitinib, despite similar immune cell infiltration. Additionally, PTH-CBD-treated mice exhibited increased beta-catenin production in hair follicles. The findings suggest that PTH-CBD can promote hair regrowth comparable to ruxolitinib, potentially by enhancing beta-catenin production and stimulating the anagen phase transition of hair follicles.
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