Dendritic Cell Subsets In Alopecia Areata: Focus On Plasmacytoid Dendritic Cells And Langerhans Cells In Immune Imbalance And Therapeutic Implications

    庄承杰, Xiuzu Song
    Studysummary This article reviews the roles of dendritic cells in alopecia areata and highlights emerging precision therapies that target these cells, reporting no new experimental findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on tandfonline.com →
    Discuss this study in the Community →

    Research cited in this study 45

    1. Comprehensive Single-Cell Transcriptomic Profiling of the Scalp from Patients with Moderate-to-Severe Alopecia Areata Journal of Allergy and Clinical Immunology · 2026
    2. The Beard Score: A Practical Tool to Assess Beard Involvement in Alopecia Areata International Journal of Dermatology · 2026
    3. Single-Cell Analysis of Temporal Immune Cell Dynamics in Alopecia Areata Reveals a Causal Role for Clonally Expanded CD8+ T Cells in Disease Cell Reports · 2025
    4. Macrophage-Centric Immunometabolic Crosstalk in Alopecia Areata Pathogenesis: Mechanisms and Therapeutic Implications Clinical Reviews in Allergy & Immunology · 2025
    5. Modulating Immune Responses in Alopecia: Therapeutic Insights and Potential Targets of Antisense Oligonucleotides BMC Immunology · 2025
    6. Hair Follicle Targeting Via Gelatin Coated Transferosomes Loaded With Tofacitinib Citrate For Enhanced Treatment Of Alopecia Areata: Clinical Evaluation Of Alopecia Areata Patients International Journal of Pharmaceutics · 2025
    7. The Role of Reactive Oxygen Species in the Pathogenesis of Alopecia Areata: A Systematic Review and Meta-Analysis Skin Pharmacology and Physiology · 2025
    8. Humanized CXCL12 Antibody Delays Onset and Modulates Immune Response in Alopecia Areata Mice: Insights from Single-Cell RNA Sequencing Frontiers in Immunology · 2024
    9. Intranasal Sensitization Model of Alopecia Areata Using Pertussis Toxin as Adjuvant Frontiers in Immunology · 2024
    10. Predictors And Management Of Inadequate Response To JAK Inhibitors In Alopecia Areata American Journal of Clinical Dermatology · 2024
    11. Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Tofacitinib for Treating Alopecia Areata Journal of Controlled Release · 2024
    12. Real-World Effectiveness and Safety of Tofacitinib for Alopecia Areata: A Retrospective Cohort Study of 202 Patients Australasian Journal of Dermatology · 2024
    13. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    14. Microneedle-Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia Advanced Materials · 2024
    15. Role of Neurogenic Inflammation in the Pathogenesis of Alopecia Areata The Journal of Dermatology · 2024
    16. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    17. Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates Pharmaceuticals · 2024
    18. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    19. Functional Interrogation of Lymphocyte Subsets in Alopecia Areata Using Single-Cell RNA Sequencing Proceedings of the National Academy of Sciences · 2023
    20. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    21. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    22. The Potential of Regulatory T Cell-Based Therapies for Alopecia Areata Frontiers in Immunology · 2023
    23. Novel Potential Therapeutic Targets of Alopecia Areata Frontiers in Immunology · 2023
    24. Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata eLife · 2023
    25. Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata Dermatology and therapy · 2023
    26. Alopecia Areata in Latin America: Where Are We and Where Are We Going? Dermatology and Therapy · 2022
    27. How Our Microbiome Influences the Pathogenesis of Alopecia Areata Genes · 2022
    28. Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata Frontiers in immunology · 2022
    29. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    30. Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? Frontiers in Immunology · 2022
    31. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021
    32. Immunological Properties of Atopic Dermatitis-Associated Alopecia Areata International Journal of Molecular Sciences · 2021
    33. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    34. The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020
    35. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    36. A Transcriptomic Map of Murine and Human Alopecia Areata JCI Insight · 2020
    37. Frontiers in Alopecia Areata Pathobiology Research ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2019
    38. Hair Regrowth Following Fecal Microbiota Transplantation in an Elderly Patient with Alopecia Areata: A Case Report and Review of the Literature World journal of clinical cases · 2019
    39. Identification of Blood MicroRNA Alterations in Patients With Severe Active Alopecia Areata Journal of Cellular Biochemistry · 2019
    40. Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity British journal of dermatology/British journal of dermatology, Supplement · 2019
    41. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    42. Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata Frontiers in immunology · 2018
    43. Mechanisms of Tolerance and Potential Therapeutic Interventions in Alopecia Areata Pharmacology & therapeutics · 2017
    44. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    45. Plasmacytoid Dendritic Cells in Alopecia Areata: Missing Link? Journal of the European Academy of Dermatology and Venereology · 2014