Hair Follicle Targeting Via Gelatin Coated Transferosomes Loaded With Tofacitinib Citrate For Enhanced Treatment Of Alopecia Areata: Clinical Evaluation Of Alopecia Areata Patients

    January 2025 in “ International Journal of Pharmaceutics ”
    Hamss Gabr, Mohammad Abdel‐Halim, Basma Mourad, Mai Rady, Samar Mansour
    TLDR The treatment showed significant hair regrowth in alopecia areata patients without side effects.
    The study explored the use of gelatin-coated transferosomes (GLTS) to deliver tofacitinib citrate directly to hair follicles for treating alopecia areata (AA). Involving 7 patients with stubborn AA lesions, the GLTS gel demonstrated effective localization in hair follicles and resulted in significant hair regrowth, with up to 80% improvement after 12 weeks. The treatment was well-tolerated and did not cause systemic side effects, indicating that GLTS gel could be a promising first-line treatment for persistent AA patches.
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