The Role of Reactive Oxygen Species in the Pathogenesis of Alopecia Areata: A Systematic Review and Meta-Analysis

January 2025 in “ Skin Pharmacology and Physiology ”

Jonah Perlmutter, Polycronis P. Akouris, S. Frémont, Brian Yang, Éva Szabóné Tóth, Michael O. Eze, Marni Wiseman

alopecia areata reactive oxygen species oxidative stress oxidative stress index malondialdehyde superoxide dismutase glutathione peroxidase paraoxonase-1 antioxidant-based therapies AA ROS MDA SOD GSH-Px PON1

Studysummary This study found that alopecia areata patients have elevated oxidative stress markers, such as OSI and MDA, and reduced antioxidant enzyme activities, suggesting a significant role for oxidative stress in the disease and potential value in targeting it therapeutically.

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