Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study

July 2022 in “ Indian journal of dermatology, venereology, and leprology ”

Safoura Shakoei, Hossein Mirmiranpoor, Manouchehr Nakhjavani, Maryam Nasimi, Ghazaleh Bakhshi, Arghavan Azizpour

alopecia areata oxidative stress antioxidant capacity advanced glycation end products advanced oxidation protein products paraoxonase-1 lecithin-cholesterol acyltransferase ferric-reducing antioxidant power fasting blood sugar C-reactive protein hair loss antioxidants AGEs AOPPs PON1 LCAT FRAP blood sugar CRP

TLDR Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.

This study compared oxidative stress and antioxidant markers in 40 patients with alopecia areata (AA) and 40 healthy controls, finding significantly higher oxidative stress markers and lower antioxidant activity in AA patients. The results suggest an impaired oxidant-antioxidant system in AA, with a potential role for oxidative stress in its development. However, the small sample size and cross-sectional design limit the ability to establish causality, indicating a need for further research with larger sample sizes.

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Research cited in this study

7 / 7 results

research Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

16 citations, December 2018 in “Skin pharmacology and physiology”

People with Alopecia Areata have higher oxidative stress and different enzyme activities compared to healthy individuals.

research Alopecia Areata of the Beard: A Review of the Literature

16 citations, May 2017 in “American Journal of Clinical Dermatology”

The document concludes that more research is needed to understand and treat Beard Alopecia Areata due to limited current knowledge and evidence.

research Investigation of Oxidative Stress in Patients with Alopecia Areata and Its Relationship with Disease Severity, Duration, Recurrence, and Pattern

35 citations, December 2014 in “Clinical and experimental dermatology”

Oxidative stress may play a role in causing alopecia areata.

research Oxidative Stress in Alopecia Areata: A Case-Control Study

62 citations, July 2013 in “American Journal of Clinical Dermatology”

Alopecia areata patients have higher oxidative stress and lower antioxidant levels.

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Non-ablative fractional laser treatments have a low risk of side effects in Asian patients.

research Oxidative Stress and Autoimmune Skin Disease

73 citations, January 2013 in “European journal of dermatology/EJD. European journal of dermatology”

Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.

research Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia

55 citations, January 2000 in “Cell biochemistry and function”

Alopecia patients have lower antioxidants and higher lipid damage in their blood.

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community People need to start accepting that only medical therapy (Fin/Dut) can save your hair in the long run.

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research Serum Zinc Concentration in Patients With Alopecia Areata

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