Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study

    July 2022 in “ Indian journal of dermatology, venereology, and leprology ”
    Safoura Shakoei, Hossein Mirmiranpoor, Manouchehr Nakhjavani, Maryam Nasimi, Ghazaleh Bakhshi, Arghavan Azizpour
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    TLDR Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.
    This study compared oxidative stress and antioxidant markers in 40 patients with alopecia areata (AA) and 40 healthy controls, finding significantly higher oxidative stress markers and lower antioxidant activity in AA patients. The results suggest an impaired oxidant-antioxidant system in AA, with a potential role for oxidative stress in its development. However, the small sample size and cross-sectional design limit the ability to establish causality, indicating a need for further research with larger sample sizes.
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