Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study
July 2022
in “
Indian journal of dermatology, venereology, and leprology
”
alopecia areata oxidative stress antioxidant capacity advanced glycation end products advanced oxidation protein products paraoxonase-1 lecithin-cholesterol acyltransferase ferric-reducing antioxidant power fasting blood sugar C-reactive protein hair loss antioxidants AGEs AOPPs PON1 LCAT FRAP blood sugar CRP
TLDR Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.
This study compared oxidative stress markers and antioxidant capacity in 40 patients with alopecia areata and 40 healthy controls. Results showed significantly higher levels of advanced glycation end products and advanced oxidation protein products in patients with alopecia areata, while antioxidant enzymes like paraoxonase-1, lecithin-cholesterol acyltransferase, and ferric-reducing antioxidant power were significantly lower. Additionally, higher fasting blood sugar levels were observed in patients. The study found a significant association between ferric-reducing antioxidant power and both the percentage of hair loss and serum C-reactive protein levels. The findings suggest an impaired oxidant-antioxidant enzymatic system in alopecia areata, though the cross-sectional design limits causal conclusions.
