Adverse Events of Non-Ablative Fractional Laser Photothermolysis: A Retrospective Study of 856 Treatments in 362 Patients

    Sang Min Lee, Myoung Shin Kim, Youn Jin Kim, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon, Sung Eun Chang
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    TLDR Non-ablative fractional laser treatments have a low risk of side effects in Asian patients.
    The retrospective study of 856 treatments of non-ablative fractional laser photothermolysis (NAFP) in 362 Korean patients reported an overall adverse event incidence of 5.0%. The most common issues were prolonged erythema (1.8%), post-inflammatory hyperpigmentation (PIH) (1.1%), and aggravation of melasma (0.9%), with less frequent events like herpes simplex outbreak (0.6%) and acneiform eruption (0.2%). No long-term adverse events were observed. The study concluded that NAFP is a safe procedure with a low complication rate for Asian patients with skin phototypes III-IV, although it acknowledged the limitations of its retrospective nature and potential missed follow-ups.
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