An Update in the Management of Alopecia Areata

    July 2023 in “ IntechOpen eBooks
    Alberto Soto‐Moreno, Clara Ureña-Paniego, Trinidad Montero‐Vílchez, Salvador Arias‐Santiago
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    TLDR New treatments for alopecia areata show promise, but more research is needed to confirm their effectiveness.
    Alopecia Areata (AA) is a common type of non-scarring alopecia with no current preventive or curative treatment. It is caused by an aberrant immune response leading to premature transition of hair follicles from anagen to catagen and telogen phase. Treatments include topical and oral minoxidil, corticosteroids, and newer therapies like Janus kinase inhibitors. A study with 45 participants showed platelet-rich plasma was superior to triamcinolone acetonide in inducing hair growth, while another study with 19,218 patients showed that oral administration of low-dose minoxidil improved 18 to 82.4% of patients. However, further large-scale studies are needed to evaluate the efficacy of these treatments. Other treatments like Apremilast, Dupilumab, and Abatacept have varying degrees of efficacy. The document emphasizes the importance of shared decision-making between patients and healthcare providers in choosing the most suitable treatment option.
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      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

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      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.
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      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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