Intranasal Sensitization Model of Alopecia Areata Using Pertussis Toxin as Adjuvant

    October 2024 in “ Frontiers in Immunology ”
    Yuying Liu, Jasmin Freeborn, Beanna Okeugo … J. Marc Rhoads
    Studysummary This study proposes that intranasal exposure to PTx and autoantigen in an animal model can trigger autoimmune disease, supporting the idea that subclinical nasal colonization by BP may cause alopecia areata.
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    Research cited in this study 13

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    2. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    3. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    4. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    5. Distinguishing Immunohistochemical Features of Alopecia Areata from Androgenic Alopecia Journal of Cosmetic Dermatology · 2018
    6. Immune Privilege Collapse And Alopecia Development: Is Stress A Factor Skin Appendage Disorders · 2017
    7. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    8. Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies Autoimmunity reviews · 2016
    9. Distinguishing Diffuse Alopecia Areata from Pattern Hair Loss Using CD3+ T Cells Journal of The American Academy of Dermatology · 2016
    10. Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata Journal of Investigative Dermatology · 2015
    11. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    12. Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis Histopathology · 2009
    13. The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results Experimental dermatology · 2008