Single-Cell Analysis of Temporal Immune Cell Dynamics in Alopecia Areata Reveals a Causal Role for Clonally Expanded CD8+ T Cells in Disease

    June 2025 in “ Cell Reports ”
    Zhenpeng Dai, Yuqian Chang, Eunice Lee … Angela M. Christiano
    Studysummary In this study using the C3H/HeJ mouse model of alopecia areata, researchers found that hyperexpanded CD8<sup>+</sup> T cell clones were sufficient to initiate disease, establishing a causal link between T cell clonality and pathogenicity.
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    Research cited in this study 15

    1. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    2. Functional Interrogation of Lymphocyte Subsets in Alopecia Areata Using Single-Cell RNA Sequencing Proceedings of the National Academy of Sciences · 2023
    3. Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
    4. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    5. A Transcriptomic Map of Murine and Human Alopecia Areata JCI Insight · 2020
    6. High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata JCI insight · 2018
    7. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    8. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    9. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    10. Rapid Skin Repigmentation on Oral Ruxolitinib in a Patient with Coexistent Vitiligo and Alopecia Areata Journal of the American Academy of Dermatology · 2015
    11. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    12. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    13. Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis Histopathology · 2009
    14. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005
    15. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998

    Related research 1

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023