Deciphering the Cellular Landscape and Genetic Underpinnings of Fiber Diameter Determined by Dermal Papilla Cells in Fine-Wool Sheep

    Tong Xiao, Tingting Guo, Chao Yuan … Jianbin Liu
    Studysummary In this study, researchers used single-cell RNA sequencing to map the hair follicle microenvironment in fine-wool sheep, identifying specific cell types and gene expressions that influence wool fiber diameter, with dermal papilla cells playing a significant role in hair follicle development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 34

    1. Immunological Control of Skin Development: From Homeostasis to Developmental Pathologies Frontiers in Immunology · 2025
    2. Functional Regeneration Strategies of Hair Follicles: Advances and Challenges Stem Cell Research & Therapy · 2025
    3. Phenotypic, Transcriptomic, and Genomic Analyses Reveal the Spatiotemporal Patterns and Associated Genes of Coarse Hair Density in Goats 动物学研究 · 2025
    4. FGF20 Secreted From Dermal Papilla Cells Regulates the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine-Wool Sheep Journal of Animal Physiology and Animal Nutrition · 2024
    5. Screening and Expression Validation of Key Proteins for Secondary Hair Follicle Growth in Cashmere Goats Based on iTRAQ Quantitative Proteomics Technology Frontiers in Veterinary Science · 2024
    6. CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway Genes · 2024
    7. Transcriptome Meta-Analysis Reveals Genetic Rules in Six Animal Breeds and Genes Associated with Wool Fineness Frontiers in Genetics · 2024
    8. Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits International journal of molecular sciences · 2024
    9. Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep International journal of molecular sciences · 2024
    10. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    11. Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness Animals · 2023
    12. Molecular and Spatial Landmarks of Early Mouse Skin Development Developmental cell · 2023
    13. Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits Biology · 2023
    14. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    15. LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis Scientific Reports · 2022
    16. Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats Genomics · 2022
    17. Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature Frontiers in cell and developmental biology · 2021
    18. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    19. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    20. Discovery of Genes and Proteins Possibly Regulating Mean Wool Fibre Diameter Using cDNA Microarray and Proteomic Approaches Scientific reports · 2020
    21. Synchronous Profiling and Analysis of mRNAs and ncRNAs in the Dermal Papilla Cells from Cashmere Goats BMC genomics · 2019
    22. Effects of All-Trans Retinoic Acid on Goat Dermal Papilla Cells Cultured In Vitro Electronic Journal of Biotechnology · 2018
    23. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    24. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    25. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    26. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    27. Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling Developmental biology · 2008
    28. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    29. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    30. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    31. Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation EMBO journal · 2003
    32. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    33. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    34. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999