Discovery of Genes and Proteins Possibly Regulating Mean Wool Fibre Diameter Using cDNA Microarray and Proteomic Approaches

May 2020 in “ Scientific reports ”

Jinshan Zhao, Huaiyuan Qin, Jingjing Xin, Nan Liu, Rongwei Han, Flor M. Pérez-Campo, Hegang Li

Studysummary In this study, microarray and proteomic analyses indicated that genes involved in immune response, receptor binding, and growth factor activity might influence wool fibre diameter in sheep.

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research Identification of Skin-Expressed Genes Possibly Associated with Wool Growth Regulation of Aohan Fine Wool Sheep

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research Identification of MicroRNAs in Wool Follicles During Anagen, Catagen, and Telogen Phases in Tibetan Sheep

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research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

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research The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity

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research Upregulation of Genes Orchestrating Keratinocyte Differentiation, Including the Novel Marker Gene ID2, by Contact Sensitizers in Human Bulge-Derived Keratinocytes

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research Fundamental Hair Follicle Biology and Fine Fibre Production in Animals

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research The Up-Regulation of 14-3-3 Proteins in Smad4 Deficient Epidermis and Hair Follicles at Catagen

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research Dissecting the Impact of Chemotherapy on the Human Hair Follicle

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research Biology of the Wool Follicle: An Excursion into a Unique Tissue Interaction System Waiting to Be Rediscovered

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research Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells

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research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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research Molecular Principles of Hair Follicle Induction and Morphogenesis

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