Integrative Transcriptomic and Metabolomic Analyses Reveal the Role of Melatonin in Promoting Secondary Hair Follicle Development in Cashmere Goats

    February 2025 in “ BMC Genomics ”
    Xiaogao Diao, Jiaxin Qin, Chenxi Dong … Wei Zhang
    Studysummary This study found that in cashmere goats, melatonin treatments enhanced cashmere growth by stimulating secondary hair follicles, increasing follicle density, and improving yield and quality, highlighting key genes and metabolic pathways involved in this process.
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    Research cited in this study 15

    1. Metabolomics Reveals Metabolites Associated with Hair Follicle Cycle in Cashmere Goats BMC veterinary research · 2024
    2. Melatonin Promotes the Development of Secondary Hair Follicles by Regulating circMPP5 Journal of Animal Science and Biotechnology · 2023
    3. Integrated Transcriptomics and Metabolomics Analyses of Stress-Induced Murine Hair Follicle Growth Inhibition Frontiers in molecular biosciences · 2022
    4. Proteomics Analysis of the Secondary Hair Follicle Cycle in Liaoning Cashmere Goat Small ruminant research · 2021
    5. Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape BMC genomics · 2020
    6. Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Cashmere Follicle Transition in Cashmere Goats BMC genomics · 2020
    7. The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development Animals · 2019
    8. Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis Journal of Pineal Research · 2019
    9. A Liposome-Based Formulation Containing Equol, Dihomo-γ-Linolenic Acid, and Propionyl-L-Carnitine to Prevent and Treat Hair Loss: A Prospective Investigation Dermatologic Therapy · 2018
    10. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    11. L-Carnitine-L-Tartrate Promotes Human Hair Growth In Vitro Experimental Dermatology · 2007
    12. Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen) ˜The œAmerican journal of pathology · 2006
    13. The Effect of Melatonin Treatment on Fur Maturation Period and Hair Follicle Cycle in Growing Chinchillas Animal Science/Animal science · 2002
    14. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    15. Melatonin and Fleece Growth in Australian Cashmere Goats Small ruminant research · 1995

    Related research 6

    1. Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats Genomics · 2022
    2. Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape BMC genomics · 2020
    3. Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Hair Follicle Cycling in Cashmere Goats Research Square (Research Square) · 2019
    4. Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus) Genetics and molecular research · 2015
    5. Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling PloS one · 2013
    6. Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat Journal of integrative agriculture/Journal of Integrative Agriculture · 2012