Transcriptome Meta-Analysis Reveals Genetic Rules in Six Animal Breeds and Genes Associated with Wool Fineness

    June 2024 in “ Frontiers in Genetics ”
    Pu Xue, Shengchao Ma, Bingru Zhao … Xuefeng Fu
    Studysummary This study analyzed RNA-seq data from various animal breeds and suggested that similar molecular mechanisms may underlie wool fineness in different sheep breeds. Researchers identified 32 candidate genes related to hair follicle regulation, providing insights for molecular breeding and evolutionary studies.
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    Research cited in this study 14

    1. Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness Animals · 2023
    2. Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia Frontiers in Medicine · 2023
    3. Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits Biology · 2023
    4. Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep BMC genomics · 2022
    5. Identification of Key Genes and Signaling Pathways Related to Hetian Sheep Wool Density by RNA-Seq Technology PLOS ONE · 2022
    6. Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus BMC Genomics · 2022
    7. Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats Genes · 2021
    8. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    9. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017
    10. NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    11. Polymorphisms of FST Gene and Their Association with Wool Quality Traits in Chinese Merino Sheep PloS one · 2017
    12. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    13. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    14. Patterns of Epithelial Expression of Fos Protein Suggest Important Role in the Transition from Viable to Cornified Cell During Keratinization Development · 1991

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    2. Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape BMC genomics · 2020
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