Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options

    January 2021 in “Clinical and Experimental Medicine
    Ann Sterkens, Julien Lambert, Bervoets An
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    TLDR The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.
    The document from 2021 provides a detailed review of Alopecia Areata (AA), an autoimmune condition leading to hair loss, and discusses its diagnosis, potential immunological causes, and various treatment options. It highlights the role of immune privilege collapse and the involvement of dendritic cells in the disease's etiopathogenesis. The review mentions several treatments, including corticosteroids, minoxidil, UVB therapy, PUVA therapy, systemic treatments like methotrexate and cyclosporine, and emerging therapies such as JAK-STAT inhibitors and Platelet-Rich Plasma (PRP) therapy. However, it emphasizes that there is no cure for AA, treatments are aimed at symptom management, and relapses are common. The document concludes that more extensive research is needed to confirm the efficacy of these treatments and that individualized treatment plans are necessary due to the lack of general treatment guidelines for AA.
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