Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

    Erna Raja, Maria Thea Rane Dela Cruz Clarin, Hiromi Yanagisawa
    Studysummary This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 39

    1. Organ Function Is Preserved Despite Reorganization of Niche Architecture in the Hair Follicle Cell stem cell · 2023
    2. Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging Nature Aging · 2023
    3. Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration Cold Spring Harbor Perspectives in Biology · 2022
    4. Aging in the Sebaceous Gland Frontiers in Cell and Developmental Biology · 2022
    5. Thy1 Marks a Distinct Population of Slow-Cycling Stem Cells in the Mouse Epidermis Nature communications · 2022
    6. Sox2 in the Dermal Papilla Regulates Hair Follicle Pigmentation Cell reports · 2022
    7. Fibroblast Heterogeneity in Healthy and Wounded Skin Cold Spring Harbor Perspectives in Biology · 2022
    8. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021
    9. Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development EMBO reports · 2021
    10. Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions Nature communications · 2021
    11. Stem and Progenitor Cells in Sebaceous Gland Development, Homeostasis, and Pathologies Experimental dermatology · 2021
    12. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    13. The Pathobiology of Skin Aging American Journal Of Pathology · 2020
    14. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    15. Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo The EMBO Journal · 2019
    16. Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense Journal of Investigative Dermatology · 2019
    17. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    18. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019
    19. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    20. Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing Molecular Systems Biology · 2018
    21. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    22. Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology Experimental Dermatology · 2018
    23. Fibroblast Heterogeneity: Implications for Human Disease Journal of Clinical Investigation · 2018
    24. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017
    25. Subpopulations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Using Skin Substitutes in the Clinic British Journal of Dermatology · 2017
    26. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    27. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    28. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    29. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015
    30. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    31. CCN2 Modulates Hair Follicle Cycling in Mice Molecular Biology of the Cell · 2013
    32. Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus Journal of Investigative Dermatology · 2013
    33. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    34. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    35. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    36. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    37. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    38. Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase Journal of Investigative Dermatology · 2003
    39. The Role of VEGF and Thrombospondins in Skin Angiogenesis Journal of Dermatological Science · 2000