Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology

    March 2018 in “ Experimental Dermatology ”
    Ken Natsuga, Mika Watanabe, Wataru Nishie, Hiroshi Shimizu
    Studysummary This review explores the physiological roles of collagen XVII in the epidermis, its involvement in stem cell maintenance, and its connections with signaling pathways, but it reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    2. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    3. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015
    4. Epidermal Polarity Genes in Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014
    5. Long-Term Survival of Type XVII Collagen Revertant Cells in an Animal Model of Revertant Cell Therapy Journal of Investigative Dermatology · 2013
    6. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    7. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    8. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002

    Related research 1

    1. Ultrastructural Study on Connective Tissue-Epithelial Junctions in Anagen Hair Follicle of Human Fetus Han-guk hyeonmigyeong hakoeji/Applied microscopy · 1997