Role of Prostaglandins in Androgenetic Alopecia

    August 2026 in “ Prostaglandins & Other Lipid Mediators ”
    Jiayi Hu, Lihua Liao, 杨希婷 … Hongming Zhou
    Studysummary This review suggests that imbalance in prostaglandin levels may contribute to androgenetic alopecia, highlighting prostaglandins as potential biomarkers and therapeutic targets for the condition.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 40

    1. Targeted Transferosomal Delivery of Cetirizine: A New Approach to Alopecia Management PLoS ONE · 2026
    2. Androgenetic Alopecia Risk in Allergic Rhinitis: A Cohort Study of Immune and Antihistamine Effects World Allergy Organization Journal · 2026
    3. Nanotechnology-Based Strategies for Hair Regeneration: Mechanistic Insights and Translational Perspectives for Androgenetic Alopecia Biomedicines · 2026
    4. Use of Genetics in the Prediction of Success in Male Pattern Hair Loss Therapy and Mechanistic Studies Frontiers in Pharmacology · 2026
    5. Use of Castor Oil in Dermatology: A Narrative Review Cureus · 2026
    6. Integrated Multi-Omics Analysis Reveals Dysregulated Lipid Metabolism as a Novel Mechanism in Androgenetic Alopecia Biomedicines · 2026
    7. Bletilla Striata Polysaccharide Promotes Hair Growth and Suppresses Oxidative Stress and Senescence of Dermal Papilla Cells by Inhibiting Prostaglandin-Endoperoxide Synthase 2 International Journal of Biological Macromolecules · 2026
    8. 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells Molecules · 2025
    9. Using the Mechanisms of Action Involved in the Pathogenesis of Androgenetic Alopecia to Treat Hair Loss International Journal of Molecular Sciences · 2025
    10. Rebamipide Induces Hair Regeneration Through EP4-Driven Lipid Metabolism Remodeling International Journal of Molecular Sciences · 2025
    11. Advances in Transdermal Delivery Systems for Treating Androgenetic Alopecia Pharmaceutics · 2025
    12. Frontiers in the Physiology of Male Pattern Androgenetic Alopecia: Beyond the Androgen Horizon Physiological Reviews · 2025
    13. Prostaglandin F2α Stimulates Growth of Human Intermediate Hair Follicles in Ex Vivo Organ Culture with Potential Clinical Relevance Frontiers in Physiology · 2025
    14. Pathogenic Mechanisms And Mechanism-Directed Therapies For Androgenetic Alopecia: Current Understanding And Future Directions Dermatologic Therapy · 2025
    15. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024
    16. Physical Treatments and Therapies for Androgenetic Alopecia Journal of Clinical Medicine · 2024
    17. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2024
    18. Trichoscopy of Androgenetic Alopecia: A Systematic Review Journal of clinical medicine · 2024
    19. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024
    20. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    21. The Efficacy of Topical Prostaglandin Analogs for Hair Loss: A Systematic Review and Meta-Analysis Frontiers in Medicine · 2023
    22. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2 Cells · 2023
    23. Comparison Between Topical Cetirizine With Minoxidil Versus Topical Placebo With Minoxidil In Female Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Study Archives of Dermatological Research · 2022
    24. Latanoprost-Loaded Nanotransfersomes Designed For Scalp Administration Enhance Keratinocytes Proliferation Molecular Pharmaceutics · 2022
    25. Enhancement of Hair Growth Through Stimulation of Hair Follicle Stem Cells by Prostaglandin E2 Collagen Matrix Experimental cell research · 2022
    26. The Physiological and Pharmacological Roles of Prostaglandins in Hair Growth The Korean Journal of Physiology and Pharmacology · 2022
    27. Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial Clinical, Cosmetic and Investigational Dermatology · 2021
    28. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study Journal of Pharmacy and Pharmaceutical Sciences · 2021
    29. The Role of Prostaglandins in Androgenetic Alopecia International Journal of Dermatology · 2021
    30. Therapeutic Implications of Topical Cetirizine 1% in Treatment of Male Androgenetic Alopecia: A Case-Controlled Study Journal of Cosmetic Dermatology · 2021
    31. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018
    32. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    33. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017
    34. Bimatoprost for the Treatment of Eyelash, Eyebrow, and Scalp Alopecia Expert Opinion on Investigational Drugs · 2017
    35. Lipid Profile in Patients with Androgenetic Alopecia: A Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2016
    36. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    37. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    38. A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2011
    39. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    40. Prostaglandin Metabolism in Human Hair Follicle Experimental Dermatology · 2007