Using the Mechanisms of Action Involved in the Pathogenesis of Androgenetic Alopecia to Treat Hair Loss

The document reviews the pathogenesis and treatment of androgenetic alopecia (AGA), emphasizing the roles of genetic and androgenic factors, particularly dihydrotestosterone (DHT) and androgen receptors, in hair follicle miniaturization. Current FDA-approved treatments, Minoxidil and Finasteride, are effective but require lifelong use. New pharmacological therapies targeting AGA's mechanisms, such as growth factors like IGF-1 and VEGF, are explored for potentially more effective treatments. Combining drugs has shown better outcomes, as demonstrated in studies where combinations like Minoxidil and Finasteride significantly improved hair growth. A study with 40 men using a combined topical treatment (TH07) showed promising results, with 52% experiencing dense hair growth. Overall, these treatments are well-tolerated, with no significant adverse effects reported.