Targeted Transferosomal Delivery of Cetirizine: A New Approach to Alopecia Management

    April 2026 in “ PLoS ONE ”
    Noha Talal Zelai
    Studysummary In this study, incorporating cetirizine into transferosome formulations significantly enhanced hair growth in mice and boosted IGF-1 and VEGF levels, suggesting that this method could be a promising alternative to traditional hair growth treatments, though further studies are needed to confirm its safety and suitability.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.plos.org →
    Discuss this study in the Community →

    Research cited in this study 20

    1. Androgenetic Alopecia and Risks of Overall and Aggressive Prostate Cancer: An Updated Systematic Review and Meta-Analysis Cancers · 2025
    2. Epidemiological Landscape of Androgenetic Alopecia in the US: An All of Us Cross-Sectional Study PLoS ONE · 2025
    3. Male Androgenetic Alopecia Anais Brasileiros de Dermatologia · 2025
    4. Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular Targeting in Androgenic Alopecia Topical Treatment Pharmaceutics · 2024
    5. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    6. Synergistic Therapeutic Effect of Ginsenoside Rg3 Modified Minoxidil Transfersomes on Androgenic Alopecia in C57BL/6 Mice International Journal of Pharmaceutics · 2024
    7. Topical Cetirizine for the Management of Androgenic Alopecia: Results of a Pilot Study Journal of Cosmetic Dermatology · 2023
    8. Formulation Optimization, In Vitro and In Vivo Evaluation of Niosomal Nanocarriers for Enhanced Topical Delivery of Cetirizine Saudi Pharmaceutical Journal · 2023
    9. The Preparation of High Minoxidil Loaded Transfersomes and Its Gel for Effective Topical Treatment of Alopecia Journal of Drug Delivery Science and Technology · 2023
    10. The Efficacy of Topical Prostaglandin Analogs for Hair Loss: A Systematic Review and Meta-Analysis Frontiers in Medicine · 2023
    11. The Physiological and Pharmacological Roles of Prostaglandins in Hair Growth The Korean Journal of Physiology and Pharmacology · 2022
    12. Transferosomes Versus Transethosomes for the Dermal Delivery of Minoxidil: Preparation and In Vitro/Ex Vivo Appraisal Journal of Drug Delivery Science and Technology · 2022
    13. Phyllanthus Emblica Extract-Loaded Transfersomes for Hair Follicle Targeting: Phytoconstituents, Characterization, and Hair Growth Promotion Journal of Oleo Science · 2022
    14. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    15. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study Journal of Pharmacy and Pharmaceutical Sciences · 2021
    16. Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice International Journal of Nanomedicine · 2019
    17. Finasteride Nano-Transferosomal Gel Formula for Management of Androgenetic Alopecia: Ex Vivo Investigational Approach Drug Design Development and Therapy · 2018
    18. A Preliminary Study on Topical Cetirizine in the Therapeutic Management of Androgenetic Alopecia Journal of Dermatological Treatment · 2017
    19. Female Pattern Hair Loss: A Clinical and Pathophysiological Review Anais Brasileiros De Dermatologia · 2015
    20. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012